Journal article
Efficacy of low-dose oral use of type I interferon in cytomegalovirus infections in vivo
Journal of Interferon & Cytokine Research, Vol.19(8), pp.869-876
1999
Abstract
Oral administration of type I interferons (IFNs; murine IFN-α and IFN- β) reduces early replication of murine cytomegalovirus (MCMV) in both the spleen and liver of MCMV-infected BALB/c mice. Examination of a range of doses of IFN (1 to 1000 IU) showed that 10 IU administered daily for 1 week prior to virus infection was optimal for inhibition of MCMV replication. Furthermore, low-dose orally administered IFN (10 IU/day) was effective in mice challenged with lethal and sublethal virus inocula. The antiviral efficacy of low-dose orally administered IFN was not restricted by either the route of virus inoculation or the mouse genotype. Analysis by immunohistochemistry of IFN-α receptor-bearing cells of the gastrointestinal tract revealed predominant staining of perivascular smooth muscle and the lamina propria of the anterior tongue, small intestine and rectum. These tissues, dense in IFN-α receptor-bearing cells, are likely to be the sites of interaction of the orally administered IFNs with the mucosal immune system. In conclusion, we propose that low-dose oral use of type I IFN therapy may have broad applications in the treatment of CMV infections.
Details
- Title
- Efficacy of low-dose oral use of type I interferon in cytomegalovirus infections in vivo
- Authors/Creators
- E. Bosio (Author/Creator)M.W. Beilharz (Author/Creator)M.W. Watson (Author/Creator)C.M. Lawson (Author/Creator)
- Publication Details
- Journal of Interferon & Cytokine Research, Vol.19(8), pp.869-876
- Publisher
- Mary Ann Liebert Inc.
- Identifiers
- 991005544428307891
- Murdoch Affiliation
- School of Veterinary and Biomedical Sciences
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.6 Immunology
- 1.6.106 Interferons
- Web Of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology
- Immunology
- ESI research areas
- Immunology