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Journal article
Egg reappearance periods of anthelmintics against equine cyathostomins: The state of play revisited
International journal for parasitology -- drugs and drug resistance, Vol.21, pp.28-39
2023
Abstract
Cyathostomins are the most common and highly prevalent parasites of horses worldwide. Historically, the control of cyathostomins has mainly relied on the routine use of anthelmintic products. Increasing reports on anthelmintic resistance (AR) in cyathostomins are concerning. A potential method proposed for detecting emerging AR in cyathostomins has been estimating the egg reappearance period (ERP). This paper reviews the data available for the ERP of cyathostomins against the three major classes of anthelmintics, macrocyclic lactones, tetrahydropyrimidines, and benzimidazoles. Published peer-reviewed original research articles were obtained from three databases (PubMed, CAB Direct and Web of Science) and were evaluated for their inclusion in a systematic review. Subsets of articles were then subjected to a review of ERP data. A total of 54 (of 134) studies published between 1972 and 2022 met the criteria for inclusion in the systematic review. Until the beginning of 2022, there was no agreed definition of the ERP; eight definitions of ERP were identified in the literature, complicating the comparison between studies. Additionally, potential risk factors for the shortening of the ERP, including previous anthelmintic use and climate, were frequently not described. Reports of shortened ERP for moxidectin and ivermectin are frequent: 20 studies that used comparable ERP definitions reported shortened moxidectin and ivermectin ERPs of 35 and 28 days, respectively. It is unclear whether the ERPs of these anthelmintics reduced to such levels are due to the development of AR or some biological factors related to horses, cyathostomin species, and/or the environment. The ERPs for other anthelmintics, such as fenbendazole and pyrantel, were frequently not reported due to established resistance against these drugs. Future research in horses is required to understand the mechanism(s) behind the shortening of ERP for cyathostomins. Based on this systematic review, we propose recommendations for future ERP studies.
Details
- Title
- Egg reappearance periods of anthelmintics against equine cyathostomins: The state of play revisited
- Authors/Creators
- S. L. MacdonaldG. Abbas - The University of MelbourneA. Ghafar - The University of MelbourneC.G. Gauci - The University of MelbourneJ. Bauquier - The University of MelbourneC. El-Hage - The University of MelbourneB. Tennent-Brown - The University of MelbourneE.J.A. WilkesA. Beasley - The University of QueenslandCaroline L Jacobson - Murdoch University, Centre for Animal Production and HealthL. CudmoreP. CarriganJ. HurleyI. BeveridgeK. J. HughesM. K. NielsenA. Jabbar - The University of Melbourne
- Publication Details
- International journal for parasitology -- drugs and drug resistance, Vol.21, pp.28-39
- Publisher
- Elsevier Ltd on behalf of Australian Society for Parasitology
- Identifiers
- 991005562568907891
- Copyright
- © 2022 The Authors.
- Murdoch Affiliation
- Centre for Animal Production and Health; School of Agricultural Sciences
- Resource Type
- Journal article
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Source: InCites
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.163 Parasitology - General
- 1.163.1022 Anthelmintic Resistance
- Web Of Science research areas
- Parasitology
- Pharmacology & Pharmacy
- ESI research areas
- Microbiology