Journal article
Elastic properties of the central airways in obstructive lung diseases measured using anatomical optical coherence tomography
American journal of respiratory and critical care medicine, Vol.183(5), pp.612-619
2011
PMID: 20851930
Abstract
Rationale: Our understanding of how airway remodeling affects regional airway elastic properties is limited due to technical difficulties in quantitatively measuring dynamic, in vivo airway dimensions. Such knowledge could help elucidate mechanisms of excessive airway narrowing.
Objectives: To use anatomical optical coherence tomography (aOCT) to compare central airway elastic properties in control subjects and those with obstructive lung diseases.
Methods: After bronchodilation, airway lumen area (Ai) was measured using aOCT during bronchoscopy in control subjects (n = 10) and those with asthma (n = 16), chronic obstructive pulmonary disease (COPD) (n = 9), and bronchiectasis (n = 8). Ai was measured in each of generations 0 to 5 while airway pressure was increased from −10 to 20 cm H2O. Airway compliance (Caw) and specific compliance (sCaw) were derived from the transpulmonary pressure (Pl) versus Ai curves.
Measurements and Main Results: Caw decreased progressively as airway generation increased, but sCaw did not differ appreciably across the generations. In subjects with asthma and bronchiectasis, Caw and sCaw were similar to control subjects and the Pl-Ai curves were left-shifted. No significant differences were observed between control and COPD groups.
Conclusions: Proximal airway elastic properties are altered in obstructive lung diseases. Although central airway compliance does not differ from control subjects in asthma, bronchiectasis, or COPD, Ai is lower in asthma and the Pl-Ai relationship is left-shifted in both asthma and bronchiectasis, suggesting that airways are maximally distended at lower inflating pressures. Such changes reflect alteration in the balance between airway wall distensibility and radial traction exerted on airways by surrounding lung parenchyma favoring airway narrowing.
Details
- Title
- Elastic properties of the central airways in obstructive lung diseases measured using anatomical optical coherence tomography
- Authors/Creators
- Jonathan P. Williamson - Sir Charles Gairdner Hosp, Dept Pulm Physiol, Perth, WA, AustraliaRobert A. McLaughlin - School of Electrical, Electronic and Computer EngineeringWilliam J. Noffsingerl - Sir Charles Gairdner Hosp, Dept Pulm Physiol, Perth, WA, AustraliaAlan L. James - School of Medicine and PharmacologyVanessa A. Baker - School of Anatomy, Physiology and Human BiologyAndrea Curatolo - School of Electrical, Electronic and Computer EngineeringJulian J. Armstrong - Univ Western Australia, Sch Elect Elect & Comp Engn, Opt Biomed Engn Lab, Perth, WA 6009, AustraliaAdrian Regli - School of Medicine and PharmacologyKelly L. Shepherd - Univ Western Australia, Sch Anat & Human Biol, Perth, WA 6009, AustraliaGuy B. Marks - College Station Medical CenterDavid D. Sampson - School of Electrical, Electronic and Computer EngineeringDavid R. Hillman - School of SurgeryPeter R. Eastwood - School of Anatomy, Physiology and Human Biology
- Publication Details
- American journal of respiratory and critical care medicine, Vol.183(5), pp.612-619
- Publisher
- Amer Thoracic Soc
- Number of pages
- 8
- Grant note
- AstraZeneca University of Western Australia Sir Charles Gairdner Hospital 513854; 463926; 513704 / Australian National Health and Medical Research Council (NHMRC); National Health and Medical Research Council (NHMRC) of Australia Boehringer Ingelheim Apnex Medical Inc NHMRC, Australia; National Health and Medical Research Council (NHMRC) of Australia Raine Medical Research Foundation
- Identifiers
- 991005592653007891
- Copyright
- © 2011 The American Thoracic Society
- Murdoch Affiliation
- Vice Chancellery
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 5 Physics
- 5.250 Imaging & Tomography
- 5.250.1350 Optical Coherence Tomography
- Web Of Science research areas
- Critical Care Medicine
- Respiratory System
- ESI research areas
- Clinical Medicine