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Journal article
Elevated plasma sclerostin is associated with high brain amyloid-β load in cognitively normal older adults
NPJ Aging, Vol.9(1), 17
2023
PMID: 37666862
Abstract
Osteoporosis and Alzheimer’s disease (AD) mainly affect older individuals, and the possibility of an underlying link contributing to their shared epidemiological features has rarely been investigated. In the current study, we investigated the association between levels of plasma sclerostin (SOST), a protein primarily produced by bone, and brain amyloid-beta (Aβ) load, a pathological hallmark of AD. The study enrolled participants meeting a set of screening inclusion and exclusion criteria and were stratified into Aβ− (n = 65) and Aβ+ (n = 35) according to their brain Aβ load assessed using Aβ-PET (positron emission tomography) imaging. Plasma SOST levels, apolipoprotein E gene (APOE) genotype and several putative AD blood-biomarkers including Aβ40, Aβ42, Aβ42/Aβ40, neurofilament light (NFL), glial fibrillary acidic protein (GFAP), total tau (t-tau) and phosphorylated tau (p-tau181 and p-tau231) were detected and compared. It was found that plasma SOST levels were significantly higher in the Aβ+ group (71.49 ± 25.00 pmol/L) compared with the Aβ− group (56.51 ± 22.14 pmol/L) (P < 0.01). Moreover, Spearman’s correlation analysis showed that plasma SOST concentrations were positively correlated with brain Aβ load (ρ = 0.321, P = 0.001). Importantly, plasma SOST combined with Aβ42/Aβ40 ratio significantly increased the area under the curve (AUC) when compared with using Aβ42/Aβ40 ratio alone (AUC = 0.768 vs 0.669, P = 0.027). In conclusion, plasma SOST levels are elevated in cognitively unimpaired older adults at high risk of AD and SOST could complement existing plasma biomarkers to assist in the detection of preclinical AD.
Details
- Title
- Elevated plasma sclerostin is associated with high brain amyloid-β load in cognitively normal older adults
- Authors/Creators
- Jun Yuan (Author) - Nedlands, WA Australia Nedlands, WA AustraliaSteve Pedrini (Author) - Joondalup, WA AustraliaRohith Thota (Author) - North Ryde, NSW AustraliaJames Doecke (Author) - Brisbane, QLD AustraliaPratishtha Chatterjee (Author) - Joondalup, WA Australia North Ryde, NSW AustraliaHamid Sohrabi (Author)Charlotte E. Teunissen (Author) - Amsterdam, The NetherlandsInge M. W. Verberk (Author) - Amsterdam, The NetherlandsErik Stoops (Author) - 9052 Gent, BelgiumHugo Vanderstichele (Author) - Biomarkable BV, Gent, BelgiumBruno P. Meloni (Author) - Nedlands, WA AustraliaChristopher Mitchell (Author) - Nedlands, WA AustraliaStephanie R Rainey-Smith (Author) - Joondalup, WA Australia Perth, WA AustraliaKathryn Goozee (Collaborator) - North Ryde, NSW Australia Macquarie Park, NSW AustraliaAndrew Chi Pang Tai (Author) - Nedlands, WA Australia Nedlands, WA AustraliaNicholas Ashton (Author) - Mölndal, Sweden Mölndal, SwedenHenrik Zetterberg (Author) - Mölndal, Sweden Mölndal, Sweden London, UK London, UK Hong Kong, ChinaKaj Blennow (Author) - Mölndal, Sweden Mölndal, SwedenJunjie Gao (Author) - Shanghai, ChinaFrank Mastaglia (Author) - Nedlands, WA AustraliaDelin Liu (Author) - Nedlands, WA Australia Nedlands, WA AustraliaCharles Inderjeeth (Author) - Perth, WA Australia Sir Charles Gairdner and Osborne Park Health Care Group, Perth, AustraliaMinghao Zheng (Corresponding Author) - Nedlands, WA Australia Nedlands, WA AustraliaRalph N Martins (Author) - Joondalup, WA Australia North Ryde, NSW Australia Perth, WA Australia Joondalup, WA Australia
- Publication Details
- NPJ Aging, Vol.9(1), 17
- Publisher
- Nature Publishing Group UK
- Identifiers
- 991005602467907891
- Copyright
- © 2023 The Author(s)
- Murdoch Affiliation
- Centre for Healthy Ageing; School of Psychology
- Language
- English
- Resource Type
- Journal article
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