Journal article
Elevated serum ceruloplasmin levels are associated with higher impulsivity in people with Parkinson’s Disease
Parkinson's Disease, Vol.2020, pp.1-7
2020
Abstract
Background. Heightened impulsivity has been reported in a subset of people with Parkinson’s disease (PwP) and is considered a risk factor for the development of impulse control disorders (ICDs). However, at present, there are no recognised biochemical markers of heightened impulsivity. Objectives. To determine if ceruloplasmin, a serum marker involved in the regulation of iron and copper homeostasis, is associated with trait impulsivity in PwP. Methods. The study measured serum ceruloplasmin and impulsivity using the Barratt Impulsiveness Scale (BIS-11) in an Australian cohort of 214 PwP. Multivariate general linear models (GLMs) were used to identify whether higher serum ceruloplasmin levels (>75th percentile) were significantly predictive of BIS-11 scores. Results. Serum ceruloplasmin was higher in females with PD (p<0.001) and associated with MDS-UPDRS III, Hoehn and Yahr, and ACE-R scores (p<0.05). When correcting for covariates, higher serum ceruloplasmin concentrations were associated with the 2nd order nonplanning impulsivity and with the 1st order self-control and cognitive complexity impulsivity domains. Conclusions. Higher serum ceruloplasmin levels are independently associated with heightened nonplanning impulsivity in PwP. Thus, serum ceruloplasmin levels may have clinical utility as a marker for heightened impulsivity in PD.
Details
- Title
- Elevated serum ceruloplasmin levels are associated with higher impulsivity in people with Parkinson’s Disease
- Authors/Creators
- M.C. Bakeberg (Author/Creator) - Perron Institute for Neurological and Translational ScienceM. Riley (Author/Creator) - Perron Institute for Neurological and Translational ScienceM. Byrnes (Author/Creator) - Perron Institute for Neurological and Translational ScienceA. Jefferson (Author/Creator) - Perron Institute for Neurological and Translational ScienceS. Ghosh (Author/Creator) - Perron Institute for Neurological and Translational ScienceM.K. Horne (Author/Creator) - Florey Institute of Neuroscience and Mental HealthS. McGregor (Author/Creator) - Florey Institute of Neuroscience and Mental HealthR. Stell (Author/Creator) - Perron Institute for Neurological and Translational ScienceS. Walters (Author/Creator) - Perron Institute for Neurological and Translational ScienceT. Evans (Author/Creator) - The University of Notre Dame AustraliaK. Roberts (Author/Creator) - Perron Institute for Neurological and Translational ScienceF.L. Mastaglia (Author/Creator) - Murdoch UniversityR.S. Anderton (Author/Creator) - Perron Institute for Neurological and Translational ScienceC. Ferrarese (Author/Creator)
- Publication Details
- Parkinson's Disease, Vol.2020, pp.1-7
- Publisher
- Hindawi
- Identifiers
- 991005543957207891
- Copyright
- © 2020 Megan C. Bakeberg et al.
- Murdoch Affiliation
- Centre for Molecular Medicine and Innovative Therapeutics
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.52 Neurodegenerative Diseases
- 1.52.67 Parkinson's Disease
- Web Of Science research areas
- Clinical Neurology
- ESI research areas
- Clinical Medicine