Elucidating causative gene variants in hereditary Parkinson's disease in the Global Parkinson's Genetics Program (GP2)

Lara Lange; Micol Avenali; Melina Ellis; Anastasia J. Illarionova; Ignacio Keller Sarmiento; Ai-Huey Tan; Harutyun Madoev; Caterina Galandra; Johanna Junker; Karisha Roopnarain; Justin Solle; Claire Wegel; Zih-Hua Fang; Peter R. Heutink; Kishore Kumar; Shen-Yang Lim; Enza Maria Valente; Mike Nalls; Cornelis Blauwendraat; Andrew Singleton; Niccolo Mencacci; Katja Lohmann; Christine Klein; Sulev Koks; Global Parkinsons Genetic Program

doi:10.1038/s41531-023-00526-9

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Elucidating causative gene variants in hereditary Parkinson's disease in the Global Parkinson's Genetics Program (GP2)

Journal article

Open access

Peer reviewed

Elucidating causative gene variants in hereditary Parkinson's disease in the Global Parkinson's Genetics Program (GP2)

Lara Lange, Micol Avenali, Melina Ellis, Anastasia J. Illarionova, Ignacio Keller Sarmiento, Ai-Huey Tan, Harutyun Madoev, Caterina Galandra, Johanna Junker, Karisha Roopnarain, …

NPJ Parkinson's Disease, Vol.9, 100

2023

DOI: https://doi.org/10.1038/s41531-023-00526-9

PMID: 37369645

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Abstract

Life Sciences & Biomedicine

Neurosciences

Neurosciences & Neurology

Science & Technology

The Monogenic Network of the Global Parkinson's Genetics Program (GP2) aims to create an efficient infrastructure to accelerate the identification of novel genetic causes of Parkinson's disease (PD) and to improve our understanding of already identified genetic causes, such as reduced penetrance and variable clinical expressivity of known disease-causing variants. We aim to perform short- and long-read whole-genome sequencing for up to 10,000 patients with parkinsonism. Important features of this project are global involvement and focusing on historically underrepresented populations.

Details

Title: Elucidating causative gene variants in hereditary Parkinson's disease in the Global Parkinson's Genetics Program (GP2)
Authors/Creators: Lara Lange - University of Lübeck
Micol Avenali - University of Pavia
Melina Ellis - Anzac Research Institute
Anastasia J. Illarionova - German Center for Neurodegenerative Diseases
Ignacio Keller Sarmiento - Northwestern Univ, Dept Neurol, Feinberg Sch Med, Chicago, IL USA
Ai-Huey Tan - University of Malaya
Harutyun Madoev - University of Lübeck
Caterina Galandra - University of Pavia
Johanna Junker - University of Lübeck
Karisha Roopnarain - University of Lübeck
Justin Solle - Michael J. Fox Foundation
Claire Wegel - Indiana University – Purdue University Indianapolis
Zih-Hua Fang - German Center for Neurodegenerative Diseases
Peter R. Heutink - German Center for Neurodegenerative Diseases
Kishore Kumar - Garvan Institute of Medical Research
Shen-Yang Lim - University of Pavia
Enza Maria Valente - University of Pavia
Mike Nalls - Data Tecnica International (United States)
Cornelis Blauwendraat - National Institute of Neurological Disorders and Stroke
Andrew Singleton - National Institute on Aging
Niccolo Mencacci - Northwestern University
Katja Lohmann - University of Lübeck
Christine Klein - University of Lübeck
Sulev Koks - Murdoch University, Centre for Molecular Medicine and Innovative Therapeutics
Global Parkinsons Genetic Program
Publication Details: NPJ Parkinson's Disease, Vol.9, 100
Publisher: NATURE PORTFOLIO
Number of pages: 5
Grant note: Michael J. Fox Foundation for Parkinson's Research; Michael J Fox Foundation Aligning Science Against Parkinson's (ASAP) initiative Aligning Science Across Parkinson's Initiative; Aligning Science Across Parkinson's (ASAP)
Identifiers: 991005606969707891
Murdoch Affiliation: Centre for Molecular Medicine and Innovative Therapeutics
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.52 Neurodegenerative Diseases; 1.52.67 Parkinson's Disease
Web Of Science research areas: Neurosciences
ESI research areas: Neuroscience & Behavior