Journal article
Emergence and global spread of epidemic healthcare-associated Clostridium difficile
Nature Genetics, Vol.45(1), pp.109-113
2012
Abstract
Epidemic C. difficile (027/BI/NAP1) has rapidly emerged in the past decade as the leading cause of antibiotic-associated diarrhea worldwide. However, the key events in evolutionary history leading to its emergence and the subsequent patterns of global spread remain unknown. Here, we define the global population structure of C. difficile 027/BI/NAP1 using whole-genome sequencing and phylogenetic analysis. We show that two distinct epidemic lineages, FQR1 and FQR2, not one as previously thought, emerged in North America within a relatively short period after acquiring the same fluoroquinolone resistance-conferring mutation and a highly related conjugative transposon. The two epidemic lineages showed distinct patterns of global spread, and the FQR2 lineage spread more widely, leading to healthcare-associated outbreaks in the UK, continental Europe and Australia. Our analysis identifies key genetic changes linked to the rapid transcontinental dissemination of epidemic C. difficile 027/BI/NAP1 and highlights the routes by which it spreads through the global healthcare system.
Details
- Title
- Emergence and global spread of epidemic healthcare-associated Clostridium difficile
- Authors/Creators
- M. He (Author/Creator)F. Miyajima (Author/Creator)P. Roberts (Author/Creator)L. Ellison (Author/Creator)D.J. Pickard (Author/Creator)M.J. Martin (Author/Creator)T.R. Connor (Author/Creator)S.R. Harris (Author/Creator)D. Fairley (Author/Creator)K.B. Bamford (Author/Creator)S. D'Arc (Author/Creator)J. Brazier (Author/Creator)D. Brown (Author/Creator)J.E. Coia (Author/Creator)G.l Douce (Author/Creator)D. Gerding (Author/Creator)H.J. Kim (Author/Creator)T.H. Koh (Author/Creator)H. Kato (Author/Creator)M. Senoh (Author/Creator)T. Louie (Author/Creator)S. Michell (Author/Creator)E. Butt (Author/Creator)S.J. Peacock (Author/Creator)N.M. Brown (Author/Creator)T. Riley (Author/Creator)G. Songer (Author/Creator)M. Wilcox (Author/Creator)M. Pirmohamed (Author/Creator)E. Kuijper (Author/Creator)P.r Hawkey (Author/Creator)B.W. Wren (Author/Creator)G. Dougan (Author/Creator)J. Parkhill (Author/Creator)T.D. Lawley (Author/Creator)
- Publication Details
- Nature Genetics, Vol.45(1), pp.109-113
- Publisher
- Nature Publishing Group
- Identifiers
- 991005545208007891
- Copyright
- © 2013 Nature America, Inc.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.120 Inflammatory Bowel Diseases & Infections
- 1.120.1133 Clostridium Infections
- Web Of Science research areas
- Genetics & Heredity
- ESI research areas
- Molecular Biology & Genetics