Encapsulation: A Strategy to Deliver Therapeutics and Bioactive Compounds?

Iveta Klojdová; Tomáš Milota; Jitka Smetanová; Constantinos Stathopoulos

doi:10.3390/ph16030362

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Encapsulation: A Strategy to Deliver Therapeutics and Bioactive Compounds?

Journal article

Open access

Peer reviewed

Encapsulation: A Strategy to Deliver Therapeutics and Bioactive Compounds?

Iveta Klojdová, Tomáš Milota, Jitka Smetanová and Constantinos Stathopoulos

Pharmaceuticals (Basel, Switzerland), Vol.16(3), 362

2023

DOI: https://doi.org/10.3390/ph16030362

PMID: 36986462

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Abstract

encapsulation

functional foods

targeted therapy

food supplements

targeted distribution of therapeutics

drugs

vaccines

immunogenicity

There is a growing demand for efficient medical therapies without undesired side effects that limit their application. Targeted therapies such as deliveries of pharmacologically active compounds to a specific site of action in the human body are still a big challenge. Encapsulation is an effective tool for targeted deliveries of drugs and sensitive compounds. It has been exploited as a technique that can manage the required distribution, action and metabolism of encapsulated agents. Food supplements or functional foods containing encapsulated probiotics, vitamins, minerals or extracts are often part of therapies and currently also a consumption trend. For effective encapsulation, optimal manufacturing has to be ensured. Thus, there is a trend to develop new (or modify existing) encapsulation methods. The most-used encapsulation approaches are based on barriers made from (bio)polymers, liposomes, multiple emulsions, etc. In this paper, recent advances in the use of encapsulation in the fields of medicine, food supplements and functional foods are highlighted, with emphasis on its benefits within targeted and supportive treatments. We have focused on a comprehensive overview of encapsulation options in the field of medicine and functional preparations that complement them with their positive effects on human health.

Details

Title: Encapsulation: A Strategy to Deliver Therapeutics and Bioactive Compounds?
Authors/Creators: Iveta Klojdová - Czech University of Life Sciences Prague
Tomáš Milota - Charles University
Jitka Smetanová - University Hospital in Motol
Constantinos Stathopoulos - Czech University of Life Sciences Prague
Publication Details: Pharmaceuticals (Basel, Switzerland), Vol.16(3), 362
Publisher: MDPI
Grant note: European Union's Horizon 2020 Research and Innovation Program under grant agreement No 952594 (ERA Chair project DRIFT-FOOD) / European Union Czech Health Research Council, project no. NU22-05-00402 / Ministry of Health Czech Republic
Identifiers: 991005704925507891
Murdoch Affiliation: Food Futures Institute
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 3 Agriculture, Environment & Ecology; 3.85 Food Science & Technology; 3.85.553 Protein-Stabilized Emulsions
Web Of Science research areas: Chemistry, Medicinal; Pharmacology & Pharmacy
ESI research areas: Pharmacology & Toxicology