Journal article
Endogenous-peptide-dependent alloreactivity: new scientific insights and clinical implications
Tissue Antigens, Vol.81(6), pp.399-407
2013
Abstract
T-cell alloreactivity is generated via immune responsiveness directed against allogeneic (allo) human leucocyte antigen (HLA) molecules. Whilst the alloresponse is of extraordinary potency and frequency, it has often been assumed to be less peptide-specific than conventional T-cell reactivity. Recently, several human studies have shown that both alloreactive CD8+ and CD4+ T cells exhibit exquisite allo-HLA and endogenous peptide specificity that has also underpinned tissue-specific allorecognition. In this review, we summarize former and recent scientific evidence in support of endogenous peptide (self-peptide)-dependence of T-cell alloreactivity. The clinical implications of these findings will be discussed in the context of both solid organ transplantation and haematopoietic stem cell transplantation (HSCT). Insights into the understanding of the molecular basis of T-cell allorecognition will probably translate into improved allograft survival outcomes, lower frequencies of graft vs host disease and could potentially be exploited for selective graft vs leukaemia effect to improve clinical outcomes following HSCT.
Details
- Title
- Endogenous-peptide-dependent alloreactivity: new scientific insights and clinical implications
- Authors/Creators
- L.J. D'Orsogna (Author/Creator) - Royal Perth HospitalT.H.O. Nguyen (Author/Creator) - Monash UniversityF.H.J. Claas (Author/Creator) - Leiden UniversityC. Witt (Author/Creator) - Royal Perth HospitalN.A. Mifsud (Author/Creator) - Monash University
- Publication Details
- Tissue Antigens, Vol.81(6), pp.399-407
- Publisher
- Blackwell Publishing
- Identifiers
- 991005542915507891
- Copyright
- 2013 John Wiley and Sons Ltd
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.6 Immunology
- 1.6.127 T Cell Regulation
- Web Of Science research areas
- Cell Biology
- Immunology
- Pathology
- ESI research areas
- Molecular Biology & Genetics