Journal article
Endothelial biomarkers of thrombosis in critically ill patients with acquired coagulopathy: A prospective cohort study
Biomarkers in Medicine, Vol.16(9), Art. 0576
2022
Abstract
Background: It remains largely unknown whether endothelial biomarkers can be used to predict thromboembolism in critically ill patients with an acquired coagulopathy. Materials & methods: The ability of syndecan-1, P-selectin and microRNA expressions to predict thromboembolism were assessed in 40 critically ill coagulopathic patients. Results: The area under the receiver operating characteristic curves for syndecan-1, P-selectin and the four differentially expressed microRNAs – determined by real-time qPCR analysis – to predict thromboembolism (n = 10, 25%) were 0.71 (95% CI 0.52–0.89), 0.73 (95% CI 0.52–0.95) and >0.80, respectively. Syndecan-1 and P-selectin concentrations were also significantly correlated with one another (R = 0.41, p = 0.008). Conclusion: Endothelial function biomarkers, including endothelial microRNA expressions, were associated with subsequent thromboembolism in critically ill patients who had a deranged coagulation profile.
Details
- Title
- Endothelial biomarkers of thrombosis in critically ill patients with acquired coagulopathy: A prospective cohort study
- Authors/Creators
- Y. Harahsheh (Author/Creator)H. Ludewick (Author/Creator)W. Pavey (Author/Creator)K.M. Ho (Author/Creator)
- Publication Details
- Biomarkers in Medicine, Vol.16(9), Art. 0576
- Publisher
- Future Medicine Ltd.
- Identifiers
- 991005542837907891
- Copyright
- © 2022 Future Science Group
- Murdoch Affiliation
- School of Veterinary and Life Sciences
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.196 Micro & Long Noncoding RNA
- 1.196.68 MicroRNA in Cancer
- Web Of Science research areas
- Medicine, Research & Experimental
- ESI research areas
- Molecular Biology & Genetics