Journal article
Enhanced corticomotor excitability with dynamic fatiguing exercise of the lower limb in multiple sclerosis
Journal of Neurology, Vol.255(7), pp.1001-1005
2008
Abstract
Objective
To determine if task performance and fatigability during rapid repetitive exercise of the lower limb differ in a group of MS subjects compared to a control group, and what central changes accompany the development of fatigue and the period of recovery.
Methods
Transcranial magnetic stimulation (TMS) was used to compare motor evoked potential (MEP) responses between 10 clinically definite MS subjects (7F, 33– 64 years of age; EDSS ≤ 4; MRC grade ≥ 4/5) and 13 control subjects during and after 5 bouts of a 15-second maximum rate foot-tapping task performed at 1 minute intervals.
Results
Maximum voluntary contraction (MVC) force of ankle dorsiflexion was lower (15 %) in the MS group compared to controls; however there were no differences in the rate of foot tapping. The rate of foot tapping decreased during each bout of exercise to a comparable degree in both groups, but there was no overall deterioration in performance across the 5 repeat bouts in either group. MS subjects showed a greater decline in strength than controls after exercise (20.7 ± 7.7 % vs. 6 ± 3.6 %; p < 0.05). MEP amplitude increased significantly for the exercised limb in both groups, but the increase was greater in MS subjects (65.9 ± 27 % vs. 31 ± 19.6 %; MS vs. control; p < 0.05). MEP amplitude also increased for the non-exercised limb in controls (40.6 ± 15.6 %, p < 0.01) but not in MS subjects.
Conclusions
Mild to moderately affected MS subjects can perform a fatiguing exercise requiring a high level of central motor control but this is associated with a greater strength loss and increase in corticomotor excitability compared to unaffected individuals.
Significance
Central adaptive processes are likely to have a significant role in maintaining task performance in MS.
Details
- Title
- Enhanced corticomotor excitability with dynamic fatiguing exercise of the lower limb in multiple sclerosis
- Authors/Creators
- G.W. Thickbroom (Author/Creator) - Queen Elizabeth II Medical CentreP. Sacco (Author/Creator) - Queen Elizabeth II Medical CentreD.L. Faulkner (Author/Creator) - Queen Elizabeth II Medical CentreA.G. Kermode (Author/Creator) - Queen Elizabeth II Medical CentreF.L. Mastaglia (Author/Creator) - Queen Elizabeth II Medical Centre
- Publication Details
- Journal of Neurology, Vol.255(7), pp.1001-1005
- Publisher
- Steinkopff Verlag
- Identifiers
- 991005542246507891
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
31 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.203 Neuromuscular Disorders
- 1.203.147 Multiple Sclerosis
- Web Of Science research areas
- Clinical Neurology
- ESI research areas
- Neuroscience & Behavior