Enhanced expression of genes related to xenobiotic metabolism in the skin of patients with atopic dermatitis but not with ichthyosis vulgaris

S. Blunder; S. Kõks; G. Kõks; E. Reimann; H. Hackl; R. Gruber; V. Moosbrugger-Martinz; M. Schmuth; S. Dubrac

doi:10.1016/j.jid.2017.08.036

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Enhanced expression of genes related to xenobiotic metabolism in the skin of patients with atopic dermatitis but not with ichthyosis vulgaris

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Enhanced expression of genes related to xenobiotic metabolism in the skin of patients with atopic dermatitis but not with ichthyosis vulgaris

S. Blunder, S. Kõks, G. Kõks, E. Reimann, H. Hackl, R. Gruber, V. Moosbrugger-Martinz, M. Schmuth and S. Dubrac

Journal of Investigative Dermatology, Vol.138(1), pp.98-108

2018

DOI: https://doi.org/10.1016/j.jid.2017.08.036

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Abstract

Previous transcriptome analyses underscored the importance of immunological and skin barrier abnormalities in atopic dermatitis (AD). We sought to identify pathogenic pathways involved in AD by comparing the transcriptomes of AD patients stratified for filaggrin (FLG)-null mutations to those of both healthy donors and patients with ichthyosis vulgaris. We applied RNA sequencing to analyze the whole transcriptome of nonlesional skin. We found that 607 genes (476 up-regulated and 131 down-regulated by >2-fold) and 193 genes (172 up-regulated and 21 down-regulated by >2-fold) were differentially expressed when all AD or ichthyosis vulgaris patients were compared with healthy donors, respectively. Expression of genes involved in RNA/protein turnover and adenosine triphosphate synthesis, as well as genes involved in cell death, response to oxidative stress, DNA damage/repair, and autophagy, were significantly enriched in AD skin and, to a lesser extent, in ichthyosis vulgaris skin. FLG-null mutations appear to hardly interfere with current observations. Genes related to xenobiotic metabolism were up-regulated in AD skin only, as were genes related to arachidonic, linoleic, and α-linolenic acid metabolism. Thus, this work newly links AD pathogenesis to aberrant expression of genes related to xenobiotic metabolism.

Details

Title: Enhanced expression of genes related to xenobiotic metabolism in the skin of patients with atopic dermatitis but not with ichthyosis vulgaris
Authors/Creators: S. Blunder (Author/Creator) - Innsbruck Medical University
S. Kõks (Author/Creator) - University of Tartu
G. Kõks (Author/Creator) - University of Tartu
E. Reimann (Author/Creator) - University of Tartu
H. Hackl (Author/Creator) - Innsbruck Medical University
R. Gruber (Author/Creator) - Innsbruck Medical University
V. Moosbrugger-Martinz (Author/Creator) - Innsbruck Medical University
M. Schmuth (Author/Creator) - Innsbruck Medical University
S. Dubrac (Author/Creator) - Innsbruck Medical University
Publication Details: Journal of Investigative Dermatology, Vol.138(1), pp.98-108
Publisher: Elsevier, Inc. on behalf of the Society for Investigative Dermatology.
Identifiers: 991005540144707891
Copyright: © 2017 The Authors.
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.65 Allergy; 1.65.1091 Atopic Dermatitis
Web Of Science research areas: Dermatology
ESI research areas: Clinical Medicine