Journal article
Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci
Nature Communications, Vol.6(1)
2015
Abstract
Psoriasis is a chronic autoimmune disease with complex genetic architecture. Previous genome-wide association studies (GWAS) and a recent meta-analysis using Immunochip data have uncovered 36 susceptibility loci. Here, we extend our previous meta-analysis of European ancestry by refined genotype calling and imputation and by the addition of 5,033 cases and 5,707 controls. The combined analysis, consisting of over 15,000 cases and 27,000 controls, identifies five new psoriasis susceptibility loci at genome-wide significance (P<5 × 10−8). The newly identified signals include two that reside in intergenic regions (1q31.1 and 5p13.1) and three residing near PLCL2 (3p24.3), NFKBIZ (3q12.3) and CAMK2G (10q22.2). We further demonstrate that NFKBIZ is a TRAF3IP2-dependent target of IL-17 signalling in human skin keratinocytes, thereby functionally linking two strong candidate genes. These results further integrate the genetics and immunology of psoriasis, suggesting new avenues for functional analysis and improved therapies.
Details
- Title
- Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci
- Authors/Creators
- L.C. Tsoi (Author/Creator) - University of MichiganS.L. Spain (Author/Creator) - King's College LondonE. Ellinghaus (Author/Creator) - Christian-Albrechts-Universität zu KielP.E. Stuart (Author/Creator) - University of MichiganF. Capon (Author/Creator) - King's College LondonJ. Knight (Author/Creator) - Guy's and St Thomas' NHS Foundation TrustT. Tejasvi (Author/Creator) - University of MichiganH.M. Kang (Author/Creator) - University of MichiganM.H. Allen (Author/Creator) - King's College LondonS. Lambert (Author/Creator) - University of MichiganS.W. Stoll (Author/Creator) - University of MichiganS. Weidinger (Author/Creator) - Christian-Albrechts-Universität zu KielJ.E. Gudjonsson (Author/Creator) - University of MichiganS. Kõks (Author/Creator) - University of TartuK. Kingo (Author/Creator) - University of TartuT. Esko (Author/Creator) - University of TartuS. Das (Author/Creator) - University of MichiganA. Metspalu (Author/Creator) - University of TartuM. Weichenthal (Author/Creator) - Christian-Albrechts-Universität zu KielC. Enerbäck (Author/Creator) - Linköping UniversityG.G. Krueger (Author/Creator) - University of UtahJ.J. Voorhees (Author/Creator) - University of MichiganV. Chandran (Author/Creator) - Toronto Western HospitalC.F. Rosen (Author/Creator) - Toronto Western HospitalP. Rahman (Author/Creator) - Memorial University of NewfoundlandD.D. Gladman (Author/Creator) - Toronto Western HospitalA. Reis (Author/Creator) - Friedrich-Alexander-Universität Erlangen-NürnbergR.P. Nair (Author/Creator) - University of MichiganA. Franke (Author/Creator) - Christian-Albrechts-Universität zu KielJ.N.W.N. Barker (Author/Creator)G.R. Abecasis (Author/Creator) - University of MichiganR.C. Trembath (Author/Creator) - Queen Mary University of LondonJ.T. Elder (Author/Creator) - Veterans Health Administration
- Publication Details
- Nature Communications, Vol.6(1)
- Publisher
- Springer Nature
- Identifiers
- 991005540548507891
- Copyright
- © 2019 Springer Nature Limited
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.106 Rheumatology
- 1.106.737 Psoriasis
- Web Of Science research areas
- Genetics & Heredity
- ESI research areas
- Molecular Biology & Genetics