Enhancing Aseptic Inflammation Resolution with 1-(2-Ethoxyethyl)-4-(pent-1-yn-1-yl)piperidin-4-yl Propionate: A Novel β-Cyclodextrin Complex as a Therapeutic Agent

Symbat Zhumakova; Aliya Tokusheva; Tolganay Zharkynbek; Marina Balabekova; Sulev Koks; Tulegen Seilkhanov; Valery Dembitsky; Alexey Zazybin; Murat Aydemir; Ulan Kemelbekov; Gulgul Kairanbayeva; Valentina Yu

doi:10.3390/molecules29215135

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Enhancing Aseptic Inflammation Resolution with 1-(2-Ethoxyethyl)-4-(pent-1-yn-1-yl)piperidin-4-yl Propionate: A Novel β-Cyclodextrin Complex as a Therapeutic Agent

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Enhancing Aseptic Inflammation Resolution with 1-(2-Ethoxyethyl)-4-(pent-1-yn-1-yl)piperidin-4-yl Propionate: A Novel β-Cyclodextrin Complex as a Therapeutic Agent

Symbat Zhumakova, Aliya Tokusheva, Tolganay Zharkynbek, Marina Balabekova, Sulev Koks, Tulegen Seilkhanov, Valery Dembitsky, Alexey Zazybin, Murat Aydemir, Ulan Kemelbekov, …

Molecules (Basel, Switzerland), Vol.29(21), 5135

2024

DOI: https://doi.org/10.3390/molecules29215135

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Abstract

1-(2-ethoxyethyl)-4-(pent-1-yn-1-yl)piperidin-4-yl propionate (<bold>EPPP</bold>)

complex <bold>EPPP</bold> with beta-cyclodextrin (<bold>EPPP beta CD</bold>)

supracomplex

aseptic inflammation

heavy metal technology-related exposure

ammonium vanadate (NH4VO3)

potassium bichromate (K2Cr2O7)

The synthesized compound, 1-(2-ethoxyethyl)-4-(pent-1-yn-1-yl)piperidin-4-yl propionate (EPPP), and its 1:1 complex with β-cyclodextrin (EPPPβCD) have been characterized for the first time through a comprehensive suite of analytical methods. This study explores the therapeutic potential of EPPPβCD in modulating immune responses and accelerating the resolution of septic inflammation induced by chromium and vanadium ions in outbred male rats. The research highlights the significant impact of EPPPβCD on the dynamics of regulatory T lymphocytes (Tregs), notably causing a reduction in the CD4+CD25+ fractions at the onset of inflammation. This effect is attributed to the inhibition of Treg proliferation, which is crucial in hastening the resolution of inflammation. These findings underscore the potential of EPPPβCD as a promising therapeutic agent in controlling and mitigating inflammation mediated by heavy metal exposure, thereby offering a new avenue for the development of anti-inflammatory treatments.

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Title: Enhancing Aseptic Inflammation Resolution with 1-(2-Ethoxyethyl)-4-(pent-1-yn-1-yl)piperidin-4-yl Propionate: A Novel β-Cyclodextrin Complex as a Therapeutic Agent
Authors/Creators: Symbat Zhumakova - Kazakh-British Technical University
Aliya Tokusheva - Kazakh National Medical University
Tolganay Zharkynbek
Marina Balabekova
Sulev Koks - Murdoch University, Centre for Molecular Medicine and Innovative Therapeutics
Tulegen Seilkhanov
Valery Dembitsky - Lethbridge College
Alexey Zazybin - Kazakh-British Technical University
Murat Aydemir - Dicle University
Ulan Kemelbekov - South Kazakhstan Medical Academy
Gulgul Kairanbayeva - Kazakh National Medical University
Valentina Yu
Publication Details: Molecules (Basel, Switzerland), Vol.29(21), 5135
Publisher: MDPI
Number of pages: 12
Grant note: AP19676539; BR21882220; AP19675500 / Committee of Science of the Ministry of Science and High Education of the Republic of Kazakhstan
Identifiers: 991005717068107891
Murdoch Affiliation: Health Futures Institute
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 3 Agriculture, Environment & Ecology; 3.91 Contamination & Phytoremediation; 3.91.1514 Hexavalent Chromium
Web Of Science research areas: Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
ESI research areas: Chemistry