EpCAM immunotherapy versus specific targeted delivery of drugs

J. Macdonald; J. Henri; K. Roy; E. Hays; M. Bauer; R. Veedu; N. Pouliot; S. Shigdar

doi:10.3390/cancers10010019

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EpCAM immunotherapy versus specific targeted delivery of drugs

Journal article

Open access

Peer reviewed

EpCAM immunotherapy versus specific targeted delivery of drugs

J. Macdonald, J. Henri, K. Roy, E. Hays, M. Bauer, R. Veedu, N. Pouliot and S. Shigdar

Cancers, Vol.10(1), E19

2018

DOI: https://doi.org/10.3390/cancers10010019

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Abstract

The epithelial cell adhesion molecule (EpCAM), or CD326, was one of the first cancer associated biomarkers to be discovered. In the last forty years, this biomarker has been investigated for use in personalized cancer therapy, with the first monoclonal antibody, edrecolomab, being trialled in humans more than thirty years ago. Since then, several other monoclonal antibodies have been raised to EpCAM and tested in clinical trials. However, while monoclonal antibody therapy has been investigated against EpCAM for almost 40 years as primary or adjuvant therapy, it has not shown as much promise as initially heralded. In this review, we look at the reasons why and consider alternative targeting options, such as aptamers, to turn this almost ubiquitously expressed epithelial cancer biomarker into a viable target for future personalized therapy.

Details

Title: EpCAM immunotherapy versus specific targeted delivery of drugs
Authors/Creators: J. Macdonald (Author/Creator) - Deakin University
J. Henri (Author/Creator) - Deakin University
K. Roy (Author/Creator) - Deakin University
E. Hays (Author/Creator) - Deakin University
M. Bauer (Author/Creator) - Deakin University
R. Veedu (Author/Creator) - Murdoch University
N. Pouliot (Author/Creator) - The University of Melbourne
S. Shigdar (Author/Creator) - Deakin University
Publication Details: Cancers, Vol.10(1), E19
Publisher: MDPI AG
Identifiers: 991005542336607891
Murdoch Affiliation: Centre for Comparative Genomics
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 2 Chemistry; 2.145 Biosensors; 2.145.243 Nanobiosensors
Web Of Science research areas: Oncology
ESI research areas: Clinical Medicine