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Journal article
Ertugliflozin decreases the insulin spike in non-insulin dysregulated standardbred horses following intra-articular triamcinolone administration
Domestic animal endocrinology, Vol.96, 107016
2026
PMID: 42056832
Abstract
Horses with equine metabolic syndrome (EMS) are at an increased risk of laminitis following corticosteroid use. Ertugliflozin reduces hyperinsulinemia in horses with EMS, and therefore may be a management option to reduce the insulin spike seen post corticosteroid use. It was hypothesised that oral ertugliflozin, administered before and after intra-articular (IA) triamcinolone acetonide (TA), will significantly lower the insulin response in comparison to placebo. A randomised, blinded, placebo-controlled, crossover design was performed on eight adult standardbred geldings with no history of laminitis. Once a day, horses were orally-administered with either 0.05 mg/kg of ertugliflozin or volume-matched placebo for four days before and four days after IA TA (18 mg) was administered into a middle carpal joint. Horses then had a two-week washout period before the same process was repeated with the alternative treatment (ertugliflozin or placebo) and opposite carpal joint injected. During the eight-day treatment periods, blood was collected each day at 8 am and 12 pm for analysis of blood insulin, glucose and triglycerides concentrations. Using Bayesian modelling, the maximum plasma insulin concentration (Cmax) for the post-TA period was 40.2 μIU/mL (95% credible interval: 13.2, 65.7) with placebo and 16.7 μIU/mL (95% CI: 1.76, 40.1) with ertugliflozin. There was a 99.13% probability that the ertugliflozin Cmax was lower than that for placebo. In conclusion, four once-daily doses of oral ertugliflozin (0.05 mg/kg) given prior to and again following IA TA administration, attenuated the rise in plasma insulin concentrations in non-insulin-dysregulated horses.[Display omitted]
Details
- Title
- Ertugliflozin decreases the insulin spike in non-insulin dysregulated standardbred horses following intra-articular triamcinolone administration
- Authors/Creators
- Cara Darch - Murdoch UniversityTimothy H. Hyndman - Murdoch University, Centre for Terrestrial Ecosystem Science and SustainabilityDavid Byrne - Murdoch University, School of Veterinary MedicineDavid Ian Rendle - EMT Consulting, West Woodburn, East Anstey, Tiverton EX16 9JU, United KingdomBarny Fraser - Murdoch University, School of Veterinary Medicine
- Publication Details
- Domestic animal endocrinology, Vol.96, 107016
- Publisher
- Elsevier Inc.; NEW YORK
- Number of pages
- 5
- Identifiers
- 991005879652307891
- Copyright
- © 2026 The Authors.
- Murdoch Affiliation
- Centre for Terrestrial Ecosystem Science and Sustainability; The Animal Hospital At Murdoch University; School of Veterinary Medicine
- Language
- English
- Resource Type
- Journal article
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