Journal article
Estimated plasma bupivacaine concentration after single dose and eight-hour continuous intra-articular infusion of bupivacaine in normal dogs
Veterinary surgery, Vol.36(8), pp.783-791
Submitted February 2007; Accepted September 2007
2007
PMID: 18067620
Abstract
Objective
To estimate maximum plasma concentration (Cmax) and time to maximum plasma (tmax) bupivacaine concentration after intra-articular administration of bupivacaine for single injection (SI) and injection followed by continuous infusion (CI) in normal dogs.
Study Design
Cross-over design with a 2-week washout period.
Animals
Healthy Coon Hound dogs (n=8).
Methods
Using gas chromatography/mass spectrometry, canine plasma bupivacaine concentration was measured before and after SI (1.5 mg/kg) and CI (1.5 mg/kg and 0.3 mg/kg/h). Software was used to establish plasma concentration–time curves and estimate Cmax, Tmax and other pharmacokinetic variables for comparison of SI and CI.
Results
Bupivacaine plasma concentration after SI and CI best fit a 3 exponential model. For SI, mean maximum concentration (Cmax, 1.33±0.954 μg/mL) occurred at 11.37±4.546 minutes. For CI, mean Cmax (1.13±0.509 μg/mL) occurred at 10.37±4.109 minutes. The area under the concentration–time curve was smaller for SI (143.59±118.390 μg/mL × min) than for CI (626.502±423.653 μg/mL × min, P=.02) and half-life was shorter for SI (61.33±77.706 minutes) than for CI (245.363±104.415 minutes, P=.01). The highest plasma bupivacaine concentration for any dog was 3.2 μg/mL for SI and 2.3 μg/mL for CI.
Conclusion
Intra-articular bupivacaine administration results in delayed absorption from the stifle into the systemic circulation with mean Cmax below that considered toxic and no systemic drug accumulation.
Clinical Relevance
Intra-articular bupivacaine can be administered with small risk of reaching toxic plasma concentrations in dogs, though toxic concentrations may be approached. Caution should be exercised with multimodal bupivacaine administration because plasma drug concentration may rise higher than with single intra-articular injection.
Details
- Title
- Estimated plasma bupivacaine concentration after single dose and eight-hour continuous intra-articular infusion of bupivacaine in normal dogs
- Authors/Creators
- LORETTA Bubenik - Louisiana State UniversityGISELLE Hosgood - Louisiana State UniversitySTEVEN Barker - Louisiana State UniversityMERRIN Hicks - Louisiana State UniversityVERNA Serra - Louisiana State UniversityRHETT Stout - Louisiana State University
- Publication Details
- Veterinary surgery, Vol.36(8), pp.783-791
- Publisher
- Blackwell Publishing Inc
- Edition
- Submitted February 2007; Accepted September 2007
- Number of pages
- 9
- Identifiers
- 991005592763507891
- Copyright
- © 2007 by The American College of Veterinary Surgeons
- Murdoch Affiliation
- School of Veterinary Medicine
- Language
- English
- Resource Type
- Journal article
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- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.43 Anesthesiology
- 1.43.202 Regional Anesthesia
- Web Of Science research areas
- Veterinary Sciences
- ESI research areas
- Plant & Animal Science