Journal article
Estimates of age-related memory decline are inflated by unrecognized Alzheimer's disease
Neurobiology of Aging, Vol.70, pp.170-179
2018
Abstract
Cognitive decline is considered an inevitable consequence of aging; however, estimates of cognitive aging may be influenced negatively by undetected preclinical Alzheimer's disease (AD). This study aimed to determine the extent to which estimates of cognitive aging were biased by preclinical AD. Cognitively normal older adults (n = 494) with amyloid-β status determined from positron emission tomography neuroimaging underwent serial neuropsychological assessment at 18-month intervals over 72 months. Estimates of the effects of age on verbal memory, working memory, executive function, and processing speed were derived using linear mixed models. The presence of preclinical AD and clinical progression to mild cognitive impairment or dementia during the study were then added to these models as covariates. Initially, age was associated with decline across all 4 cognitive domains. With the effects of elevated amyloid-β and clinical progression controlled, age was no longer associated with decline in verbal or working memory. However, the magnitude of decline was reduced only slightly for executive function and was unchanged for processing speed. Thus, considered together, the results of the study indicate that undetected preclinical AD negatively biases estimates of age-related cognitive decline for verbal and working memory.
Details
- Title
- Estimates of age-related memory decline are inflated by unrecognized Alzheimer's disease
- Authors/Creators
- K.D. Harrington (Author/Creator) - Cooperative Research Centre for Mental HealthA. Schembri (Author/Creator) - CogState Ltd., Melbourne, Victoria, Australia.Y.Y. Lim (Author/Creator) - Florey Institute of Neuroscience and Mental HealthC. Dang (Author/Creator) - The University of MelbourneD. Ames (Author/Creator) - National Ageing Research InstituteJ. Hassenstab (Author/Creator) - Washington University in St. LouisS.M. Laws (Author/Creator) - Centre for Mental HealthS. Rainey-Smith (Author/Creator)J. Robertson (Author/Creator) - Florey Institute of Neuroscience and Mental HealthC.C. Rowe (Author/Creator) - Austin HealthH.R. Sohrabi (Author/Creator) - The University of Western AustraliaO. Salvado (Author/Creator) - Biosecurity AustraliaM. Weinborn (Author/Creator) - The University of Western AustraliaV.L. Villemagne (Author/Creator) - Florey Institute of Neuroscience and Mental HealthC.L. Masters (Author/Creator) - Florey Institute of Neuroscience and Mental HealthP. Maruff (Author/Creator) - Florey Institute of Neuroscience and Mental Health
- Publication Details
- Neurobiology of Aging, Vol.70, pp.170-179
- Publisher
- Elsevier
- Identifiers
- 991005545550907891
- Copyright
- © 2018 Elsevier Inc.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Industry collaboration
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- Citation topics
- 1 Clinical & Life Sciences
- 1.52 Neurodegenerative Diseases
- 1.52.60 Dementia
- Web Of Science research areas
- Geriatrics & Gerontology
- Neurosciences
- ESI research areas
- Neuroscience & Behavior