Evaluation and histological examination of a Campylobacter fetus subsp. venerealis small animal infection model

A. Koya; S.C. de Wet; S. Turner; J. Cawdell-Smith; B. Venus; R.M. Greer; A.E. Lew-Tabor; G.B. Boe-Hansen

doi:10.1016/j.rvsc.2014.12.005

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Evaluation and histological examination of a Campylobacter fetus subsp. venerealis small animal infection model

Journal article

Open access

Peer reviewed

Evaluation and histological examination of a Campylobacter fetus subsp. venerealis small animal infection model

A. Koya, S.C. de Wet, S. Turner, J. Cawdell-Smith, B. Venus, R.M. Greer, A.E. Lew-Tabor and G.B. Boe-Hansen

Research in Veterinary Science, Vol.99, pp.1-9

2015

DOI: https://doi.org/10.1016/j.rvsc.2014.12.005

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Abstract

Bovine genital campylobacteriosis (BGC), caused by Campylobacter fetus subsp. venerealis, is associated with production losses in cattle worldwide. This study aimed to develop a reliable BGC guinea pig model to facilitate future studies of pathogenicity, abortion mechanisms and vaccine efficacy. Seven groups of five pregnant guinea pigs (1 control per group) were inoculated with one of three strains via intra-peritoneal (IP) or intra-vaginal routes. Samples were examined using culture, PCR and histology. Abortions ranged from 0% to 100% and re-isolation of causative bacteria from sampled sites varied with strain, dose of bacteria and time to abortion. Histology indicated metritis and placentitis, suggesting that the bacteria induce inflammation, placental detachment and subsequent abortion. Variation of virulence between strains was observed and determined by culture and abortion rates. IP administration of C. fetus subsp. venerealis to pregnant guinea pigs is a promising small animal model for the investigation of BGC abortion.

Details

Title: Evaluation and histological examination of a Campylobacter fetus subsp. venerealis small animal infection model
Authors/Creators: A. Koya (Author/Creator) - The University of Queensland
S.C. de Wet (Author/Creator) - Department of Agriculture, Fisheries and Forestry
S. Turner (Author/Creator) - Department of Agriculture, Fisheries and Forestry
J. Cawdell-Smith (Author/Creator) - The University of Queensland
B. Venus (Author/Creator) - The University of Queensland
R.M. Greer (Author/Creator) - The University of Queensland
A.E. Lew-Tabor (Author/Creator) - The University of Queensland
G.B. Boe-Hansen (Author/Creator) - The University of Queensland
Publication Details: Research in Veterinary Science, Vol.99, pp.1-9
Publisher: Harcourt Publishers Ltd
Identifiers: 991005543052007891
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.42 Bacteriology; 1.42.376 Salmonella and Campylobacter
Web Of Science research areas: Veterinary Sciences
ESI research areas: Plant & Animal Science