Journal article
Evaluation of Chinese medicinal herbs fingerprinting by HPLC-DAD for the detection of toxic aristolochic acids
Journal of Separation Science, Vol.34(10), pp.1111-1115
2011
Abstract
Aristolochic acids are known to contribute to various renal disorders; therefore, expanding the availability of analytical methodology to detect these compounds is important in order to assess the quality of Chinese herbal medicines in which they can be found. Twelve medicinal herbal samples were procured from various sources and extracted in duplicate prior to a “fingerprint” analysis using conventional HPLC‐DAD. Multivariate analysis was performed on the entire chromatographed fingerprints. The resulting output was a partial least‐square discriminant analysis model, which was able to evaluate the potential presence of aristolochic acids I and II as well as providing an individual herbal “fingerprint”. The results of this study provide evidence that the presence of aristolochic acids contained within certain herbal extractions could be detected using a simple method, although some limitations apply to this method for quality control, since newly detected samples for aristolochic acid (positives) will need further confirmation with purity checks or MS hyphenation.
Details
- Title
- Evaluation of Chinese medicinal herbs fingerprinting by HPLC-DAD for the detection of toxic aristolochic acids
- Authors/Creators
- J. Heaton (Author/Creator) - King's College LondonL. Whiley (Author/Creator) - King's College LondonY. Hong (Author/Creator) - King's College LondonC. Mary Sebastian (Author/Creator)N. William Smith (Author/Creator)C. Legido-Quigley (Author/Creator) - King's College London
- Publication Details
- Journal of Separation Science, Vol.34(10), pp.1111-1115
- Publisher
- Wiley
- Identifiers
- 991005544474007891
- Copyright
- © 2011 WILEY‐VCH Verlag GmbH & Co.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 3 Agriculture, Environment & Ecology
- 3.16 Phytochemicals
- 3.16.2163 Aristolochic Acid
- Web Of Science research areas
- Chemistry, Analytical
- ESI research areas
- Chemistry