Journal article
Evaluation of IL12B as a candidate type I diabetes susceptibility gene using data from the Type I Diabetes Genetics Consortium
Genes and Immunity, Vol.10, pp.S64-S68
2009
Abstract
As part of its efforts to identify genes affecting the risk of type I diabetes (T1D), the Type I Diabetes Genetics Consortium commissioned an extensive survey of variants associated with genes reported earlier to have an association with disease susceptibility. In this report, we present the analysis of a set of single-nucleotide polymorphisms (SNPs) within and flanking the IL12B gene, which encodes the p40 subunit of the cytokines interleukin (IL)-12 and IL-23. No SNP showed individually significant association in the population as a whole. Nevertheless, subjects stratified according to genotype at the earlier reported SNP in the IL12B 3′UTR, rs3212227, confirmed small, but significant, differences in age of disease onset with a relative hazard0.88 (P=0.005). The protective effect of rs3212227 allele 2 was gender specific (P=0.004 overall and P=0.0003 when unaffected siblings were considered). Among females, the 2.2 genotype was more protective, with relative hazard0.75. We conclude that while there was no major effect of IL12B polymorphisms on T1D susceptibility in the entire study group, they have an impact on a subset of at-risk individuals.
Details
- Title
- Evaluation of IL12B as a candidate type I diabetes susceptibility gene using data from the Type I Diabetes Genetics Consortium
- Authors/Creators
- G. Morahan (Author/Creator) - The University of Western AustraliaE. McKinnon (Author/Creator) - Royal Perth HospitalJ. Berry (Author/Creator) - The University of Western AustraliaB. Browning (Author/Creator) - University of AucklandC. Julier (Author/Creator) - InsermF. Pociot (Author/Creator) - Steno Diabetes CentersI. James (Author/Creator) - Royal Perth Hospital
- Publication Details
- Genes and Immunity, Vol.10, pp.S64-S68
- Publisher
- Nature Publishing Group
- Identifiers
- 991005540609007891
- Murdoch Affiliation
- Centre for Clinical Immunology and Biomedical Statistics
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
40 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.26 Diabetes
- 1.26.1016 Type 1 Diabetes
- Web Of Science research areas
- Genetics & Heredity
- Immunology
- ESI research areas
- Molecular Biology & Genetics