Journal article
Evaluation of a ferret-specific formula for determining body surface area to improve chemotherapeutic dosing
American Journal of Veterinary Research, Vol.76(2), pp.142-148
02/2015
Abstract
OBJECTIVE To use CT-derived measurements to create a ferret-specific formula for body surface area (BSA) to improve chemotherapeutic dosing. ANIMALS 25 adult ferrets (19 live and 6 cadavers). PROCEDURES Live subjects were weighed, and body measurements were obtained by each of 3 observers while ferrets were awake and anesthetized. Computed tomography was performed, and a 3-D surface model was constructed with open-source imaging software, from which BSA was estimated. The CT-derived values were compared with BSA calculated on the basis of the traditional tape method for 6 cadavers. To further validate CT analysis software, 11 geometric shapes were scanned and their CT-derived values compared with those calculated directly via geometric formulas. Agreement between methods of surface area estimation was assessed with linear regression. Ferret-specific formulas for BSA were determined with nonlinear regression models. RESULTS Repeatability among the 3 observers was good for all measurements, but some measurements differed significantly between awake and anesthetized ferrets. Excellent agreement was found between measured versus CT-derived surface area of shapes, traditional tape- versus CT-derived BSA of ferret cadavers, and CT-derived BSA of cadavers with and without monitoring equipment. All surface area formulas performed relatively similarly. CONCLUSIONS AND CLINICAL RELEVANCE CT-derived BSA measurements of ferrets obtained via open-source imaging software were reliable. On the basis of study results, the recommended formula for BSA in ferrets would be 9.94 × (body weight)(2/3); however, this represented a relatively minor difference from the feline-derived formula currently used by most practitioners and would result in little practical change in drug doses.
Details
- Title
- Evaluation of a ferret-specific formula for determining body surface area to improve chemotherapeutic dosing
- Authors/Creators
- K.L. Jones (Author/Creator)L.A. Granger (Author/Creator)M.T Kearney (Author/Creator)A.F da Cunha (Author/Creator)D.C Cutler (Author/Creator)M.E Shapiro (Author/Creator)T.N Tully (Author/Creator)K. Shiomitsu (Author/Creator)
- Publication Details
- American Journal of Veterinary Research, Vol.76(2), pp.142-148
- Publisher
- American Veterinary Medical Association
- Number of pages
- 7
- Identifiers
- 991005542918507891
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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