Journal article
Evaluation of a manual technique for detection of neutropenia and thrombocytopenia in dogs receiving chemotherapy
Journal of the American Veterinary Medical Association, Vol.220(12), pp.1805-1806
2002
Abstract
Objective - To determine accuracy of a manual technique for detection of neutropenia and thrombocytopenia in dogs receiving chemotherapy. Design - Masked prospective study. Animals - 11 dogs treated with chemotherapy for neoplasia. Procedure - 124 blood samples from dogs being treated with chemotherapy for various neoplasms were processed through an automated cell counter, and results were compared with those obtained by use of a rapid manual technique for estimating neutrophil and platelet concentrations to determine whether the manual technique could accurately detect dogs with neutropenia or thrombocytopenia. Results - By use of automated techniques, neutropenia (< 3,000 cells/μl) was detected in 17 of 124 blood samples, and thrombocytopenia (< 100,000 platelets/μl) was detected in 3 of 124 blood samples. The manual technique correctly identified 16 of 17 (94%) blood samples with neutropenia, with a specificity of 92% (98/107). The manual technique correctly identified 3 of 3 (100%) blood samples with thrombocytopenia, with specificity of 94% (114/121). Conclusions and Clinical Relevance - Manual estimates of neutrophil and platelet counts are sensitive and specific; however, a full differential cell count is still preferable.
Details
- Title
- Evaluation of a manual technique for detection of neutropenia and thrombocytopenia in dogs receiving chemotherapy
- Authors/Creators
- K.M. Wyatt (Author/Creator)G.L. Wyatt (Author/Creator)
- Publication Details
- Journal of the American Veterinary Medical Association, Vol.220(12), pp.1805-1806
- Publisher
- American Veterinary Medical Association
- Identifiers
- 991005541805407891
- Murdoch Affiliation
- School of Veterinary and Biomedical Sciences
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.307 Laboratory Medicine
- 1.307.1039 Lab Quality Control
- Web Of Science research areas
- Veterinary Sciences
- ESI research areas
- Plant & Animal Science