Evaluation of cholinergic deficiency in preclinical Alzheimer’s disease using pupillometry

S. Frost; L. Robinson; C.C. Rowe; D. Ames; C.L. Masters; K. Taddei; S.R. Rainey-Smith; R.N. Martins; Y. Kanagasingam

doi:10.1155/2017/7935406

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Evaluation of cholinergic deficiency in preclinical Alzheimer’s disease using pupillometry

Journal article

Open access

Peer reviewed

Evaluation of cholinergic deficiency in preclinical Alzheimer’s disease using pupillometry

S. Frost, L. Robinson, C.C. Rowe, D. Ames, C.L. Masters, K. Taddei, S.R. Rainey-Smith, R.N. Martins and Y. Kanagasingam

Journal of Ophthalmology, Vol.2017, Art. 7935406

2017

DOI: https://doi.org/10.1155/2017/7935406

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Abstract

Cortical cholinergic deficiency is prominent in Alzheimer's disease (AD), and published findings of diminished pupil flash response in AD suggest that this deficiency may extend to the visual cortical areas and anterior eye. Pupillometry is a low-cost, noninvasive technique that may be useful for monitoring cholinergic deficits which generally lead to memory and cognitive disorders. The aim of the study was to evaluate pupillometry for early detection of AD by comparing the pupil flash response (PFR) in AD (N = 14) and cognitively normal healthy control (HC, N = 115) participants, with the HC group stratified according to high (N = 38) and low (N = 77) neocortical amyloid burden (NAB). Constriction phase PFR parameters were significantly reduced in AD compared to HC (maximum acceleration p < 0.05, maximum velocity p < 0.0005, average velocity p < 0.005, and constriction amplitude p < 0.00005). The high-NAB HC subgroup had reduced PFR response cross-sectionally, and also a greater decline longitudinally, compared to the low-NAB subgroup, suggesting changes to pupil response in preclinical AD. The results suggest that PFR changes may occur in the preclinical phase of AD. Hence, pupillometry has a potential as an adjunct for noninvasive, cost-effective screening for preclinical AD.

Details

Title: Evaluation of cholinergic deficiency in preclinical Alzheimer’s disease using pupillometry
Authors/Creators: S. Frost (Author/Creator) - Commonwealth Scientific and Industrial Research Organisation
L. Robinson (Author/Creator) - Commonwealth Scientific and Industrial Research Organisation
C.C. Rowe (Author/Creator) - Austin Health
D. Ames (Author/Creator) - Mental Health Research Institute
C.L. Masters (Author/Creator) - Mental Health Research Institute
K. Taddei (Author/Creator) - Edith Cowan University
S.R. Rainey-Smith (Author/Creator)
R.N. Martins (Author/Creator) - Edith Cowan University
Y. Kanagasingam (Author/Creator) - Commonwealth Scientific and Industrial Research Organisation
Publication Details: Journal of Ophthalmology, Vol.2017, Art. 7935406
Publisher: Hindawi Publishing
Identifiers: 991005540792807891
Copyright: © 2017 Shaun Frost et al.
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.52 Neurodegenerative Diseases; 1.52.60 Dementia
Web Of Science research areas: Ophthalmology
ESI research areas: Clinical Medicine