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Evaluation of echocardiography and cardiac biomarker concentrations in dogs with gastric dilatation volvulus
Journal article   Peer reviewed

Evaluation of echocardiography and cardiac biomarker concentrations in dogs with gastric dilatation volvulus

B.D. Aona, J.E. Rush, E.A. Rozanski, S.M. Cunningham, C.R. Sharp and L.M. Freeman
Journal of Veterinary Emergency and Critical Care, Vol.27(6), pp.631-637
2017
DOI: https://doi.org/10.1111/vec.12667
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Abstract

Objective To assess abnormalities in concentrations of cardiac troponin I (cTnI), lactate, and N-terminal pro-B-type natriuretic peptide (NT-proBNP) in relation to arrhythmias, echocardiographic measurements, and survival in dogs with gastric dilatation volvulus (GDV). Design Prospective observational study. Setting University hospital. Animals Twenty-two dogs with naturally occurring GDV. Samples Concentrations of cTnI, plasma lactate, and NT-proBNP were recorded at presentation to the emergency room, the time closest to echocardiography, and the highest recorded concentrations during hospitalization. Interventions None. Measurements and Main Results Cardiac rhythms were categorized on a 0–4 scale (0 = no ventricular premature complexes [VPCs], 1 = single VPCs, 2 = bigeminy or trigeminy, 3 = couplets or triplets, and 4 = R-on-T phenomenon or ventricular tachycardia). Echocardiography was performed 6–18 hours postoperatively. Fifteen dogs had ventricular arrhythmias during hospitalization (Grade 1 [n = 9], Grade 4 [n = 6]). The highest recorded cTnI concentration was significantly higher in the dogs with Grade 4 (P = 0.002) or Grade 1 (P = 0.001) arrhythmias compared to dogs without arrhythmias. Plasma lactate was significantly correlated with left ventricular internal diameter in diastole (r = −0.52, P = 0.01) and systole (r = −0.57, P = 0.006), left ventricular free wall in diastole (LWDd, r = 0.59, P = 0.004), and interventricular septal thickness in diastole (IVDs, r = 0.65, P = 0.001). Dogs that did not survive to 1 week postdischarge (3/22) had a significantly thicker LVWd (P = 0.04) and IVSd (P = 0.05), and received significantly less fluids in the first 24 (P = 0.02) and 48 hours (P = 0.03) of hospitalization. Conclusions Concentrations of cTnI and NT-proBNP increased during hospitalization, but only cTnI concentrations were significantly higher in dogs with a higher arrhythmia grade. Additional research on the potential role of serial measurement of biomarkers in dogs with GDV is warranted.

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Collaboration types
Domestic collaboration
International collaboration
Citation topics
3 Agriculture, Environment & Ecology
3.232 Veterinary Sciences
3.232.1281 Veterinary Reproductive Health
Web Of Science research areas
Veterinary Sciences
ESI research areas
Plant & Animal Science
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