Evaluation of epidemiological cut-off values indicates that biocide resistant subpopulations are uncommon in natural isolates of clinically-relevant microorganisms

I. Morrissey; M.R. Oggioni; D.R. Knight; T. Curiao; T. Coque; A. Kalkanci; J.L. Martinez

doi:10.1371/journal.pone.0086669

Back

Evaluation of epidemiological cut-off values indicates that biocide resistant subpopulations are uncommon in natural isolates of clinically-relevant microorganisms

Journal article

Open access

Peer reviewed

Evaluation of epidemiological cut-off values indicates that biocide resistant subpopulations are uncommon in natural isolates of clinically-relevant microorganisms

I. Morrissey, M.R. Oggioni, D.R. Knight, T. Curiao, T. Coque, A. Kalkanci and J.L. Martinez

PloS ONE, Vol.9(1), e86669

2014

DOI: https://doi.org/10.1371/journal.pone.0086669

Files and links (2)

pdf

Evaluation of Epidemiological Cut-Off Values Indicates that Biocide Resistant Subpopulations Are Uncommon in Natural Isolates of Clinically-Relevant Microorganisms.pdfDownload View

Published (Version of Record) Open Access

url

Free to Read *No subscription requiredView

Abstract

To date there are no clear criteria to determine whether a microbe is susceptible to biocides or not. As a starting point for distinguishing between wild-type and resistant organisms, we set out to determine the minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) distributions for four common biocides; triclosan, benzalkonium chloride, chlorhexidine and sodium hypochlorite for 3319 clinical isolates, with a particular focus on Staphylococcus aureus (N = 1635) and Salmonella spp. (N = 901) but also including Escherichia coli (N = 368), Candida albicans (N = 200), Klebsiella pneumoniae (N = 60), Enterobacter spp. (N = 54), Enterococcus faecium (N = 53), and Enterococcus faecalis (N = 56). From these data epidemiological cut-off values (ECOFFs) are proposed. As would be expected, MBCs were higher than MICs for all biocides. In most cases both values followed a normal distribution. Bimodal distributions, indic

Details

Title: Evaluation of epidemiological cut-off values indicates that biocide resistant subpopulations are uncommon in natural isolates of clinically-relevant microorganisms
Authors/Creators: I. Morrissey (Author/Creator) - Quotient Clinical (United Kingdom)
M.R. Oggioni (Author/Creator) - University of Siena
D.R. Knight (Author/Creator) - Quotient Clinical (United Kingdom)
T. Curiao (Author/Creator) - Instituto Ramón y Cajal de Investigación Sanitaria
T. Coque (Author/Creator) - Instituto Ramón y Cajal de Investigación Sanitaria
A. Kalkanci (Author/Creator) - Gazi University
J.L. Martinez (Author/Creator) - Centro Nacional de Biotecnología, CSIC, Madrid, Spain
Publication Details: PloS ONE, Vol.9(1), e86669
Publisher: Public Library of Science
Identifiers: 991005540665607891
Copyright: © 2014 Morrissey et al.
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Metrics

32 File views/ downloads

62 Record Views

145 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Industry collaboration; Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.23 Antibiotics & Antimicrobials; 1.23.146 Antimicrobial Resistance
Web Of Science research areas: Microbiology
ESI research areas: Pharmacology & Toxicology