Journal article
Evaluation of hemorrhage, sample size, and collateral damage for five hepatic biopsy methods in dogs
Veterinary surgery, Vol.35(1), pp.86-93
Submitted May 2005; Accepted July 2005
2006
PMID: 16409415
Abstract
Objectives
To compare the volume of hemorrhage, number of lobules, and portal triads available for histologic evaluation, and resultant collateral damage between 5 hepatic biopsy methods: biopsy punch, biopsy needle, ligature method, laparoscopic biopsy forceps, and ultrasonically activated scalpel (UAS).
Study Design
Experimental, repeated measures, block.
Animals
Twelve adult dogs.
Methods
Biopsies were obtained from the periphery and center of the left lateral liver lobe of each dog using each of 5 biopsy techniques. Hemorrhage was quantified and compared between methods and sites. Biopsy samples were evaluated histologically to characterize collateral damage and determine the number of lobules and portal triads sampled.
Results
Regardless of technique, liver biopsy resulted in minimal hemorrhage (<2 mL). For peripheral biopsies, UAS was comparable with the ligature method, but caused significantly less hemorrhage than all other methods, whereas for central biopsies, UAS caused significantly less hemorrhage than other methods. Except for the laparoscopic biopsy forceps, UAS caused significantly more collateral damage than other methods. UAS and ligature biopsy methods yielded specimens that had more portal triads per sample than other methods. Eight of 48 biopsy needle samples were inadequate for histologic evaluation, whereas other methods yielded adequate specimens.
Conclusions
All biopsy methods produced minimal hemorrhage and except for needle biopsy yielded adequate tissue samples for histologic evaluation.
Clinical Relevance
Use of UAS is a reliable, safe alternative technique for liver biopsy and can be used laparoscopically to obtain large tissue samples.
Details
- Title
- Evaluation of hemorrhage, sample size, and collateral damage for five hepatic biopsy methods in dogs
- Authors/Creators
- SUNIL C. Vasanjee - Louisiana State UniversityLORETTA J. Bubenik - Louisiana State UniversityGISELLE Hosgood - Louisiana State UniversityRUDY Bauer - Louisiana State University
- Publication Details
- Veterinary surgery, Vol.35(1), pp.86-93
- Publisher
- Blackwell Science Inc
- Edition
- Submitted May 2005; Accepted July 2005
- Number of pages
- 8
- Identifiers
- 991005592765807891
- Copyright
- © 2006 by The American College of Veterinary Surgeons
- Murdoch Affiliation
- School of Veterinary Medicine
- Language
- English
- Resource Type
- Journal article
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- 3.232 Veterinary Sciences
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