Journal article
Evaluation of the anti-endotoxin effects of polymyxin B in a feline model of endotoxemia
Journal of Feline Medicine and Surgery, Vol.12(4), pp.278-285
2010
Abstract
Directed, effective therapies for feline sepsis are needed to reduce the high morbidity and mortality associated with this disease. We investigated the anti-endotoxin effects of polymyxin B (PMB) in a blinded, placebo controlled fashion, both ex vivo in a feline whole blood culture system and in vivo, using a low-dose endotoxin infusion in cats. Serial measures of systemic inflammation, and hemodynamic stability, were compared between groups. Ex vivo, PMB significantly decreased lipopolysaccharide-induced tumor necrosis factor (TNF) production from whole blood. PMB (1 mg/kg over 30 min) demonstrated anti-endotoxin effects in vivo, including decreased peak plasma TNF activity (P<0.001) and increased white blood cell count (P=0.019), with no adverse effects. Given the apparent safety and anti-endotoxin effects of PMB in this endotoxemia model, a carefully designed, randomized, blinded, placebo controlled clinical trial evaluating the use of PMB in naturally occurring Gram-negative feline sepsis should be considered.
Details
- Title
- Evaluation of the anti-endotoxin effects of polymyxin B in a feline model of endotoxemia
- Authors/Creators
- C.R. Sharp (Author/Creator) - University of MissouriA.E. DeClue (Author/Creator) - University of MissouriC.E. Haak (Author/Creator) - University of MissouriA.R. Honaker (Author/Creator) - University of MissouriC.R. Reinero (Author/Creator) - University of Missouri
- Publication Details
- Journal of Feline Medicine and Surgery, Vol.12(4), pp.278-285
- Publisher
- Elsevier
- Identifiers
- 991005543226807891
- Copyright
- © 2010 ISFM and AAFP
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Citation topics
- 1 Clinical & Life Sciences
- 1.6 Immunology
- 1.6.351 Sepsis Immunology
- Web Of Science research areas
- Veterinary Sciences
- ESI research areas
- Plant & Animal Science