Evaluation of the vaccination efficacy against H5N1 in domestic poultry in the Red River Delta in Vietnam

S. Desvaux; V. Grosbois; T.T.H. Pham; D.T. Dao; T.D. Nguyen; S. Fenwick; F. Roger; T. Ellis; M. Peyre

doi:10.1017/S0950268812001628

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Evaluation of the vaccination efficacy against H5N1 in domestic poultry in the Red River Delta in Vietnam

Journal article

Open access

Peer reviewed

Evaluation of the vaccination efficacy against H5N1 in domestic poultry in the Red River Delta in Vietnam

S. Desvaux, V. Grosbois, T.T.H. Pham, D.T. Dao, T.D. Nguyen, S. Fenwick, F. Roger, T. Ellis and M. Peyre

Epidemiology and Infection, Vol.141(4), pp.776-788

2012

DOI: https://doi.org/10.1017/S0950268812001628

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Abstract

The domestic poultry population in Vietnam has been vaccinated against highly pathogenic avian influenza (HPAI) H5N1 since 2005. Since then, outbreaks have continued to occur without a clear understanding of the mechanisms involved. The general objective of this study was to understand the epidemiology of the disease in the context of vaccination and to draw some conclusions about vaccination efficacy in the domestic poultry population of the Red River Delta area. Five cross-sectional surveys to measure the serological and virological prevalence in vaccinated and unvaccinated poultry were performed from the end of 2008 to June 2010. The global seroprevalence was 24% (95% confidence interval 19·9–28·2). Determinants of vaccine immunogenicity were identified separately in chickens and ducks as well as determinants of the seroconversion in unvaccinated birds. The results highlight the difficulties in maintaining good flock immunity in poultry populations using inactivated vaccine in the field with two vaccination rounds per year, and in preventing circulation of virus in co-existing unvaccinated poultry.

Details

Title: Evaluation of the vaccination efficacy against H5N1 in domestic poultry in the Red River Delta in Vietnam
Authors/Creators: S. Desvaux (Author/Creator) - CIRAD–AGIRs (Animal et gestion intégrée des risques), Montpellier, France
V. Grosbois (Author/Creator) - CIRAD–AGIRs (Animal et gestion intégrée des risques), Montpellier, France
T.T.H. Pham (Author/Creator) - CIRAD–AGIRs (Animal et gestion intégrée des risques), Montpellier, France
D.T. Dao (Author/Creator) - National Institute of Veterinary Research
T.D. Nguyen (Author/Creator)
S. Fenwick (Author/Creator) - Murdoch University
F. Roger (Author/Creator) - CIRAD–AGIRs (Animal et gestion intégrée des risques), Montpellier, France
T. Ellis (Author/Creator) - Murdoch University
M. Peyre (Author/Creator) - CIRAD–AGIRs (Animal et gestion intégrée des risques), Montpellier, France
Publication Details: Epidemiology and Infection, Vol.141(4), pp.776-788
Publisher: Cambridge University Press
Identifiers: 991005542574207891
Copyright: © Cambridge University Press 2012
Murdoch Affiliation: School of Veterinary and Biomedical Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.104 Virology - General; 1.104.126 Influenza
Web Of Science research areas: Infectious Diseases; Public, Environmental & Occupational Health
ESI research areas: Social Sciences, general