Journal article
Evidence of HIV-1 Adaptation to HLA-Restricted Immune Responses at a Population Level
Science, Vol.296(5572), pp.1439-1443
2002
Abstract
Antigen-specific T cell immunity is HLA-restricted. Human immunodeficiency virus–type 1 (HIV-1) mutations that allow escape from host immune responses may therefore be HLA allele–specific. We analyzed HIV-1 reverse transcriptase sequences from a large HLA-diverse population of HIV-1–infected individuals. Polymorphisms in HIV-1 were most evident at sites of least functional or structural constraint and frequently were associated with particular host HLA class I alleles. Absence of polymorphism was also HLA allele–specific. At a population level, the degree of HLA-associated selection in viral sequence was predictive of viral load. These results support a fundamental role for HLA-restricted immune responses in driving and shaping HIV-1 evolution in vivo.
Details
- Title
- Evidence of HIV-1 Adaptation to HLA-Restricted Immune Responses at a Population Level
- Authors/Creators
- C.B. Moore (Author/Creator)M. John (Author/Creator)I.R. James (Author/Creator)F.T. Christiansen (Author/Creator)C.S. Witt (Author/Creator)S. Mallal (Author/Creator)
- Publication Details
- Science, Vol.296(5572), pp.1439-1443
- Publisher
- American Association for the Advancement of Science
- Identifiers
- 991005543052407891
- Murdoch Affiliation
- Centre for Clinical Immunology and Biomedical Statistics
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.66 HIV
- 1.66.46 HIV Pathogenesis
- Web Of Science research areas
- Immunology
- ESI research areas
- Immunology