Evidence of altered phosphatidylcholine metabolism in Alzheimer's disease

L. Whiley; A. Sen; J. Heaton; P. Proitsi; D. García-Gómez; R. Leung; N. Smith; M. Thambisetty; I. Kloszewska; P. Mecocci; H. Soininen; M. Tsolaki; B. Vellas; S. Lovestone; C. Legido-Quigley

doi:10.1016/j.neurobiolaging.2013.08.001

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Evidence of altered phosphatidylcholine metabolism in Alzheimer's disease

Journal article

Peer reviewed

Evidence of altered phosphatidylcholine metabolism in Alzheimer's disease

L. Whiley, A. Sen, J. Heaton, P. Proitsi, D. García-Gómez, R. Leung, N. Smith, M. Thambisetty, I. Kloszewska, P. Mecocci, …

Neurobiology of Aging, Vol.35(2), pp.271-278

2014

DOI: https://doi.org/10.1016/j.neurobiolaging.2013.08.001

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Abstract

Abberant lipid metabolism is implicated in Alzheimer's disease (AD) pathophysiology, but the connections between AD and lipid metabolic pathways are not fully understood. To investigate plasma lipids in AD, a multiplatform screen (n = 35 by liquid chromatography–mass spectrometry and n = 35 by nuclear magnetic resonance) was developed, which enabled the comprehensive analysis of plasma from 3 groups (individuals with AD, individuals with mild cognitive impairment (MCI), and age-matched controls). This screen identified 3 phosphatidylcholine (PC) molecules that were significantly diminished in AD cases. In a subsequent validation study (n = 141), PC variation in a bigger sample set was investigated, and the same 3 PCs were found to be significantly lower in AD patients: PC 16:0/20:5 (p < 0.001), 16:0/22:6 (p < 0.05), and 18:0/22:6 (p < 0.01). A receiver operating characteristic (ROC) analysis of the PCs, combined with apolipoprotein E (ApoE) data, produced an area under the curve predictive value of 0.828. Confirmatory investigations into the background biochemistry indiciated no significant change in plasma levels of 3 additional PCs of similar structure, total choline containing compounds or total plasma omega fatty acids, adding to the evidence that specific PCs play a role in AD pathology.

Details

Title: Evidence of altered phosphatidylcholine metabolism in Alzheimer's disease
Authors/Creators: L. Whiley (Author/Creator) - King's College London
A. Sen (Author/Creator) - King's College London
J. Heaton (Author/Creator) - King's College London
P. Proitsi (Author/Creator) - King's College London
D. García-Gómez (Author/Creator) - Universidad de Salamanca
R. Leung (Author/Creator) - King's College London
N. Smith (Author/Creator) - King's College London
M. Thambisetty (Author/Creator) - National Institute on Aging
I. Kloszewska (Author/Creator)
P. Mecocci (Author/Creator) - University of Perugia
H. Soininen (Author/Creator) - University of Eastern Finland
M. Tsolaki (Author/Creator) - Aristotle University of Thessaloniki
B. Vellas (Author/Creator) - Department of Internal and Geriatrics Medicine, Hôpitaux de Toulouse, Toulouse, France
S. Lovestone (Author/Creator) - King's College London
C. Legido-Quigley (Author/Creator) - King's College London
Publication Details: Neurobiology of Aging, Vol.35(2), pp.271-278
Publisher: Elsevier Inc
Identifiers: 991005545358607891
Copyright: © 2014 Elsevier Inc.
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 2 Chemistry; 2.211 Mass Spectrometry; 2.211.990 Metabolomics
Web Of Science research areas: Geriatrics & Gerontology; Neurosciences
ESI research areas: Neuroscience & Behavior