Journal article
Evolution of biomarker research in autoimmunity conditions for health professionals and clinical practice
Progress in Molecular Biology and Translational Science, Vol.190(1), pp.219-276
2022
Abstract
Medical abzymology has made a great contribution to the development of general autoimmunity theory: it has put the autoantibodies (Ab) as the key brick of the theory to the level of physiological functionality by providing such Ab with the ability to catalyze and mediate direct and independent cytotoxic effect on cellular and molecular targets. Natural catalytic autoantibodies (abzymes) while being a pool of canonical Abs and possessing catalytic activity belong to the new group of physiologically active substances whose features and properties are evolutionary consolidated in one functionally active biomolecule. Therefore, further studies on Ab-mediated autoAg degradation and other targeted Ab-mediated proteolysis may provide biomarkers of newer generations and thus a supplementary tool for assessing the disease progression and predicting disability of the patients and persons at risks.
This chapter is a summary of current knowledge and prognostic perspectives toward catalytic Abs in autoimmunity and thus some autoimmune clinical cases, their role in pathogenesis, and the exploitation of both whole molecules and their constituent parts in developing highly effective targeted drugs of the future to come, and thus the therapeutic protocols being individualized.
Details
- Title
- Evolution of biomarker research in autoimmunity conditions for health professionals and clinical practice
- Authors/Creators
- A. Silverstein (Author/Creator) - Johns Hopkins UniversityA. Dudaev (Author/Creator) - Moscow State University of Printing ArtsM. Studneva (Author/Creator) - Moscow State University of Printing ArtsJ. Aitken (Author/Creator) - Otakaro Pathways, Christchurch, New ZealandS. Blokh (Author/Creator) - Filatov's Moscow Clinical Pediatric Hospital, Moscow, RussiaA.D. Miller (Author/Creator) - Mendel University in BrnoS. Tanasova (Author/Creator) - Moscow State University of Medicine and DentistryN. Rose (Author/Creator) - Bloomberg (United States)J. Ryals (Author/Creator) - Mathematics Department at Central Georgia Technical College, Warner Robins, GA, United StatesC. Borchers (Author/Creator) - McGill UniversityA. Nordström (Author/Creator) - Umeå UniversityM. Moiseyakh (Author/Creator) - Moscow State University of Printing ArtsA.S. Herrera (Author/Creator) - University of FloridaN. Skomorohov (Author/Creator) - Moscow State University of Printing ArtsT. Marshall (Author/Creator) - The University of AdelaideA. Wu (Author/Creator) - San Francisco General HospitalR.H. Cheng (Author/Creator) - University of California, DavisK. Syzko (Author/Creator) - Moscow State University of Printing ArtsP.D. Cotter (Author/Creator) - UCSF, San Francisco, CA, United StatesM. Podzyuban (Author/Creator) - Moscow State University of Printing ArtsW. Thilly (Author/Creator)P.D. Smith (Author/Creator)P. Barach (Author/Creator)K. Bouri (Author/Creator)Y. Schoenfeld (Author/Creator)E. Matsuura (Author/Creator)V. Medvedeva (Author/Creator)I. Shmulevich (Author/Creator)L. Cheng (Author/Creator) - University of California, DavisP. Seegers (Author/Creator)Y. Khotskaya (Author/Creator)K. Flaherty (Author/Creator)S. Dooley (Author/Creator)E.J. Sorenson (Author/Creator)M. Ross (Author/Creator)S. Suchkov (Author/Creator)
- Publication Details
- Progress in Molecular Biology and Translational Science, Vol.190(1), pp.219-276
- Publisher
- Academic Press
- Identifiers
- 991005542076807891
- Copyright
- © 2022 Elsevier Inc.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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