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Journal article
Evolving Identification of Blood Cells Associated with Clinically Isolated Syndrome: Importance of Time since Clinical Presentation and Diagnostic MRI
International Journal of Molecular Sciences, Vol.18(6)
06/2017
Abstract
It is not clear how the profile of immune cells in peripheral blood differs between patients with clinically isolated syndrome (CIS) and healthy controls (HC). This study aimed to identify a CIS peripheral blood signature that may provide clues for potential immunomodulatory approaches early in disease. Peripheral blood mononuclear cells (PBMCs) were collected from 18 people with CIS, 19 HC and 13 individuals with other demyelinating conditions (ODC) including multiple sclerosis (MS). Individuals with CIS separated into two groups, namely those with early (≤14 days post-diagnostic magnetic resonance imaging (MRI); n = 6) and late (≥27 days; n = 12) blood sampling. Transitional B cells were increased in the blood of CIS patients independently of when blood was taken. However, there were two time-dependent effects found in the late CIS group relative to HC, including decreased CD56bright NK cells, which correlated significantly with time since MRI, and increased CD141+ myeloid dendritic cell (mDC2) frequencies. Higher CD1c+ B cells and lower non-classical monocyte frequencies were characteristic of more recent demyelinating disease activity (ODC and early CIS). Analysing cell populations by time since symptoms (subjective) and diagnostic MRI (objective) may contribute to understanding CIS.
Details
- Title
- Evolving Identification of Blood Cells Associated with Clinically Isolated Syndrome: Importance of Time since Clinical Presentation and Diagnostic MRI
- Authors/Creators
- S. Trend (Author/Creator) - The Kids Research Institute AustraliaA. Jones (Author/Creator) - The Kids Research Institute AustraliaS. Geldenhuys (Author/Creator) - The Kids Research Institute AustraliaS. Byrne (Author/Creator) - The University of SydneyM. Fabis-Pedrini (Author/Creator) - Perron Institute for Neurological and Translational ScienceD. Nolan (Author/Creator) - Royal Perth HospitalD. Booth (Author/Creator) - Westmead Institute for Medical ResearchW. Carroll (Author/Creator) - Centre for Neuromuscular and Neurological DisordersR. Lucas (Author/Creator) - Australian National UniversityA.G. Kermode (Author/Creator) - Murdoch UniversityP. Hart (Author/Creator) - The Kids Research Institute Australia
- Publication Details
- International Journal of Molecular Sciences, Vol.18(6)
- Publisher
- MDPI AG
- Identifiers
- 991005542684507891
- Copyright
- © 2017 by the authors. Licensee MDPI, Basel, Switzerland.
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.203 Neuromuscular Disorders
- 1.203.147 Multiple Sclerosis
- Web Of Science research areas
- Biochemistry & Molecular Biology
- Chemistry, Multidisciplinary
- ESI research areas
- Chemistry