Journal article
Evolving models of the immunopathogenesis of T cell–mediated drug allergy: The role of host, pathogens, and drug response
Journal of Allergy and Clinical Immunology, Vol.136(2), pp.219-234
2015
Abstract
Immune-mediated (IM) adverse drug reactions (ADRs) are an underrecognized source of preventable morbidity, mortality, and cost. Increasingly, genetic variation in the HLA loci is associated with risk of severe reactions, highlighting the importance of T-cell immune responses in the mechanisms of both B cell–mediated and primary T cell–mediated IM-ADRs. In this review we summarize the role of host genetics, microbes, and drugs in IM-ADR development; expand on the existing models of IM-ADR pathogenesis to address multiple unexplained observations; discuss the implications of this work in clinical practice today; and describe future applications for preclinical drug toxicity screening, drug design, and development.
Details
- Title
- Evolving models of the immunopathogenesis of T cell–mediated drug allergy: The role of host, pathogens, and drug response
- Authors/Creators
- K.D. White (Author/Creator) - Vanderbilt University Medical CenterW-H Chung (Author/Creator) - Chang Gung UniversityS-L Hung (Author/Creator)S. Mallal (Author/Creator) - Vanderbilt University Medical CenterE.J. Phillips (Author/Creator) - Vanderbilt University Medical Center
- Publication Details
- Journal of Allergy and Clinical Immunology, Vol.136(2), pp.219-234
- Publisher
- Mosby Inc.
- Identifiers
- 991005540888707891
- Copyright
- © 2015 Elsevier Inc
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.265 Dermatology - Skin Allergies
- 1.265.1140 Drug Hypersensitivity
- Web Of Science research areas
- Allergy
- Immunology
- ESI research areas
- Immunology