Journal article
Ex Vivo Phenotype and Frequency of Influenza Virus-Specific CD4 Memory T Cells
Journal of Virology, Vol.78(13), pp.7284-7287
2004
Abstract
Recent advances in class II tetramer staining technology have allowed reliable direct ex vivo visualization of antigen-specific CD4 T cells. In order to define the frequency and phenotype of a prototype response to a nonpersistent pathogen, we have used such techniques to analyze influenza virus-specific memory CD4 T cells directly from blood. These responses are stably detectable ex vivo at low frequencies (range, 0.00012 to 0.0061% of CD4 T cells) and display a distinct “central memory” CD62L+ phenotype.
Details
- Title
- Ex Vivo Phenotype and Frequency of Influenza Virus-Specific CD4 Memory T Cells
- Authors/Creators
- M. Lucas (Author/Creator) - University of OxfordC. L. Day (Author/Creator) - Medawar Building for Pathogen ResearchJ. R. Wyer (Author/Creator)S. L. Cunliffe (Author/Creator) - John Radcliffe HospitalA. Loughry (Author/Creator) - Medawar Building for Pathogen ResearchA. J. McMichael (Author/Creator) - John Radcliffe HospitalP. Klenerman (Author/Creator) - Medawar Building for Pathogen Research
- Publication Details
- Journal of Virology, Vol.78(13), pp.7284-7287
- Publisher
- American Society for Microbiology
- Identifiers
- 991005539981707891
- Copyright
- @ American Society for Microbiology
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.6 Immunology
- 1.6.127 T Cell Regulation
- Web Of Science research areas
- Virology
- ESI research areas
- Microbiology