Journal article
Examination of Australian Streptococcus suis isolates from clinically affected pigs in a global context and the genomic characterisation of ST1 as a predictor of virulence
Veterinary Microbiology, Vol.226, pp.31-40
2018
Abstract
Streptococcus suis is a major zoonotic pathogen that causes severe disease in both humans and pigs. Australia’s pig herd has been quarantined for over 30 years, however S. suis remains a significant cause of disease. In this study, we investigated S. suis from 148 cases of clinical disease in pigs from 46 pig herds over a period of seven years, to determine the level of genetic difference from international isolates that may have arisen over the 30 years of separation. Isolates underwent whole genome sequencing, genome analysis and antimicrobial susceptibility testing. Data was compared at the core genome level to clinical isolates from overseas. Results demonstrated five predominant multi-locus sequence types and two major cps gene types (cps2 and 3). At the core genome level Australian isolates clustered predominantly within one large clade consisting of isolates from the UK, Canada and North America. A small proportion of Australian swine isolates (5%) were phylogenetically associated with south-east Asian and UK isolates, many of which were classified as causing systemic disease, and derived from cases of human and swine disease. Based on this dataset we provide a comprehensive outline of the current S. suis clones associated with disease in Australian pigs and their global context, with the main finding being that, despite three decades of separation, Australian S. suis are genomically similar to overseas strains. In addition, we show that ST1 clones carry a constellation of putative virulence genes not present in other Australian STs.
Details
- Title
- Examination of Australian Streptococcus suis isolates from clinically affected pigs in a global context and the genomic characterisation of ST1 as a predictor of virulence
- Authors/Creators
- M.A. O’Dea (Author/Creator) - Murdoch UniversityT. Laird (Author/Creator) - Murdoch UniversityR. Abraham (Author/Creator) - Murdoch UniversityD. Jordan (Author/Creator) - New South Wales Department of Primary IndustriesK. Lugsomya (Author/Creator) - Chulalongkorn UniversityL. Fitt (Author/Creator) - ACE Laboratory Services, Bendigo, Victoria, Australia.M. Gottschalk (Author/Creator) - Université de MontréalA. Truswell (Author/Creator) - Murdoch UniversityS. Abraham (Author/Creator) - Murdoch University
- Publication Details
- Veterinary Microbiology, Vol.226, pp.31-40
- Publisher
- Elsevier BV
- Identifiers
- 991005541272507891
- Copyright
- © 2018 Elsevier B.V.
- Murdoch Affiliation
- School of Veterinary and Life Sciences
- Language
- English
- Resource Type
- Journal article
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- 1 Clinical & Life Sciences
- 1.248 Sexually Transmitted Infections
- 1.248.1656 Pasteurella Multocida
- Web Of Science research areas
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- Veterinary Sciences
- ESI research areas
- Plant & Animal Science