Journal article
Examining the potential clinical value of curcumin in the prevention and diagnosis of Alzheimer’s disease
British Journal of Nutrition, Vol.115(3), pp.449-465
2016
Abstract
Curcumin derived from turmeric is well documented for its anti-carcinogenic, antioxidant and anti-inflammatory properties. Recent studies show that curcumin also possesses neuroprotective and cognitive-enhancing properties that may help delay or prevent neurodegenerative diseases, including Alzheimer's disease (AD). Currently, clinical diagnosis of AD is onerous, and it is primarily based on the exclusion of other causes of dementia. In addition, phase III clinical trials of potential treatments have mostly failed, leaving disease-modifying interventions elusive. AD can be characterised neuropathologically by the deposition of extracellular β amyloid (Aβ) plaques and intracellular accumulation of tau-containing neurofibrillary tangles. Disruptions in Aβ metabolism/clearance contribute to AD pathogenesis. In vitro studies have shown that Aβ metabolism is altered by curcumin, and animal studies report that curcumin may influence brain function and the development of dementia, because of its antioxidant and anti-inflammatory properties, as well as its ability to influence Aβ metabolism. However, clinical studies of curcumin have revealed limited effects to date, most likely because of curcumin's relatively low solubility and bioavailability, and because of selection of cohorts with diagnosed AD, in whom there is already major neuropathology. However, the fresh approach of targeting early AD pathology (by treating healthy, pre-clinical and mild cognitive impairment-stage cohorts) combined with new curcumin formulations that increase bioavailability is renewing optimism concerning curcumin-based therapy. The aim of this paper is to review the current evidence supporting an association between curcumin and modulation of AD pathology, including in vitro and in vivo studies. We also review the use of curcumin in emerging retinal imaging technology, as a fluorochrome for AD diagnostics.
Details
- Title
- Examining the potential clinical value of curcumin in the prevention and diagnosis of Alzheimer’s disease
- Authors/Creators
- K.G. Goozee (Author/Creator) - 1McCusker KARVIAH Research Centre,Anglican Retirement Villages,Sydney,NSW 2154,Australia.T.M. Shah (Author/Creator) - Edith Cowan UniversityH.R. Sohrabi (Author/Creator) - Edith Cowan UniversityS.R. Rainey-Smith (Author/Creator)B. Brown (Author/Creator) - Edith Cowan UniversityG. Verdile (Author/Creator) - Edith Cowan UniversityR.N. Martins (Author/Creator) - 1McCusker KARVIAH Research Centre,Anglican Retirement Villages,Sydney,NSW 2154,Australia.
- Publication Details
- British Journal of Nutrition, Vol.115(3), pp.449-465
- Publisher
- Cambridge University Press
- Identifiers
- 991005541939807891
- Copyright
- © The Authors 2015
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 3 Agriculture, Environment & Ecology
- 3.16 Phytochemicals
- 3.16.1399 Curcumin
- Web Of Science research areas
- Nutrition & Dietetics
- ESI research areas
- Agricultural Sciences