Exceptional longevity and polygenic risk for Cardiovascular Health

M. Revelas; A. Thalamuthu; C. Oldmeadow; T-J Evans; N.J. Armstrong; C. Riveros; J.B. Kwok; P.R. Schofield; H. Brodaty; R.J. Scott; J.R. Attia; P.S. Sachdev; K.A. Mather

doi:10.3390/genes10030227

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Exceptional longevity and polygenic risk for Cardiovascular Health

Journal article

Open access

Peer reviewed

Exceptional longevity and polygenic risk for Cardiovascular Health

M. Revelas, A. Thalamuthu, C. Oldmeadow, T-J Evans, N.J. Armstrong, C. Riveros, J.B. Kwok, P.R. Schofield, H. Brodaty, R.J. Scott, …

Genes, Vol.10(3)

2019

DOI: https://doi.org/10.3390/genes10030227

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Abstract

Studies investigating exceptionally long-lived (ELL) individuals, including genetic studies, have linked cardiovascular-related pathways, particularly lipid and cholesterol homeostasis, with longevity. This study explored the genetic profiles of ELL individuals (cases: n = 294, 95–106 years; controls: n = 1105, 55–65 years) by assessing their polygenic risk scores (PRS) based on a genome wide association study (GWAS) threshold of p < 5 × 10−5. PRS were constructed using GWAS summary data from two exceptional longevity (EL) analyses and eight cardiovascular-related risk factors (lipids) and disease (myocardial infarction, coronary artery disease, stroke) analyses. A higher genetic risk for exceptional longevity (EL) was significantly associated with longevity in our sample (odds ratio (OR) = 1.19–1.20, p = 0.00804 and 0.00758, respectively). Two cardiovascular health PRS were nominally significant with longevity (HDL cholesterol, triglycerides), with higher PRS associated with EL, but these relationships did not survive correction for multiple testing. In conclusion, ELL individuals did not have significantly lower polygenic risk for the majority of the investigated cardiovascular health traits. Future work in larger cohorts is required to further explore the role of cardiovascular-related genetic variants in EL.

Details

Title: Exceptional longevity and polygenic risk for Cardiovascular Health
Authors/Creators: M. Revelas (Author/Creator) - UNSW Sydney
A. Thalamuthu (Author/Creator) - UNSW Sydney
C. Oldmeadow (Author/Creator) - Hunter Medical Research Institute
T-J Evans (Author/Creator) - Tiffany & Co.
N.J. Armstrong (Author/Creator) - UNSW Sydney
C. Riveros (Author/Creator) - University of Newcastle Australia
J.B. Kwok (Author/Creator) - Neuroscience Research Australia
P.R. Schofield (Author/Creator) - Neuroscience Research Australia
H. Brodaty (Author/Creator) - UNSW Sydney
R.J. Scott (Author/Creator) - University of Newcastle Australia
J.R. Attia (Author/Creator) - John Hunter Hospital
P.S. Sachdev (Author/Creator) - Prince of Wales Hospital
K.A. Mather (Author/Creator) - UNSW Sydney
Publication Details: Genes, Vol.10(3)
Publisher: MDPI
Identifiers: 991005543695907891
Copyright: © 2019 MDPI
Murdoch Affiliation: Information Technology, Mathematics and Statistics
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.264 Longevity; 1.264.618 Aging Mechanisms
Web Of Science research areas: Genetics & Heredity
ESI research areas: Molecular Biology & Genetics