Exercise builds the scaffold of life: Muscle extracellular matrix biomarker responses to physical activity, inactivity, and aging

Georgios Mavropalias; Marni Boppart; Kayley M Usher; Miranda D Grounds; Kazunori Nosaka; Anthony J Blazevich

doi:10.1111/brv.12916

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Exercise builds the scaffold of life: Muscle extracellular matrix biomarker responses to physical activity, inactivity, and aging

Journal article

Open access

Peer reviewed

Exercise builds the scaffold of life: Muscle extracellular matrix biomarker responses to physical activity, inactivity, and aging

Georgios Mavropalias, Marni Boppart, Kayley M Usher, Miranda D Grounds, Kazunori Nosaka and Anthony J Blazevich

Biological reviews of the Cambridge Philosophical Society, Vol.98(2), pp.481-519

2023

DOI: https://doi.org/10.1111/brv.12916

PMID: 36412213

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Abstract

Biomarkers

Exercise

Extracellular Matrix - chemistry

Muscle, Skeletal - physiology

Skeletal muscle extracellular matrix (ECM) is critical for muscle force production and the regulation of important physiological processes during growth, regeneration, and remodelling. ECM remodelling is a tightly orchestrated process, sensitive to multi-directional tensile and compressive stresses and damaging stimuli, and its assessment can convey important information on rehabilitation effectiveness, injury, and disease. Despite its profound importance, ECM biomarkers are underused in studies examining the effects of exercise, disuse, or aging on muscle function, growth, and structure. This review examines patterns of short- and long-term changes in the synthesis and concentrations of ECM markers in biofluids and tissues, which may be useful for describing the time course of ECM remodelling following physical activity and disuse. Forces imposed on the ECM during physical activity critically affect cell signalling while disuse causes non-optimal adaptations, including connective tissue proliferation. The goal of this review is to inform researchers, and rehabilitation, medical, and exercise practitioners better about the role of ECM biomarkers in research and clinical environments to accelerate the development of targeted physical activity treatments, improve ECM status assessment, and enhance function in aging, injury, and disease.

Details

Title: Exercise builds the scaffold of life: Muscle extracellular matrix biomarker responses to physical activity, inactivity, and aging
Authors/Creators: Georgios Mavropalias - Discipline of Exercise Science, Murdoch University, Murdoch, WA, 6150, Australia
Marni Boppart - University of Illinois Urbana-Champaign
Kayley M Usher - The University of Western Australia
Miranda D Grounds - The University of Western Australia
Kazunori Nosaka - Edith Cowan University
Anthony J Blazevich - Edith Cowan University
Publication Details: Biological reviews of the Cambridge Philosophical Society, Vol.98(2), pp.481-519
Publisher: John Wiley & Sons Ltd on behalf of Cambridge Philosophical Society.
Identifiers: 991005599566207891
Murdoch Affiliation: Centre for Molecular Medicine and Innovative Therapeutics
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.132 Extracellular Matrix & Cell Differentiation; 1.132.1065 Collagen Disorders
Web Of Science research areas: Biology
ESI research areas: Biology & Biochemistry