Logo image
Back
Exercise mode specificity for preserving spine and hip bone mineral density in prostate cancer patients
Journal article   Peer reviewed

Exercise mode specificity for preserving spine and hip bone mineral density in prostate cancer patients

R.U. Newton, D.A. Galvão, N. Spry, D. Joseph, S.K. Chambers, R.A. Gardiner, B.A. Wall, K.A. Bolam and D.R. Taaffe
Medicine & Science in Sports & Exercise, Vol.51(4), pp.607-614
2019
DOI: https://doi.org/10.1249/MSS.0000000000001831
url
Link to Published Version *Subscription may be requiredView

Abstract

Purpose: Androgen deprivation therapy (ADT) in men with prostate cancer (PCa) is associated with an array of adverse effects, including reduced bone mineral density (BMD) predisposing patients to increased fracture risk. Our purpose was to examine the effects of targeted exercise modes on BMD in men with PCa undergoing ADT. Methods: Between 2009 and 2012, 154 PCa patients 43-90 yr old on ADT were randomized to exercise targeting the musculoskeletal system (impact loading + resistance training [ImpRes], n = 57) supervised for 12 months, cardiovascular and muscular systems (aerobic + resistance training, n = 50) supervised for 6 months followed by a 6-month home-based program, or delayed aerobic exercise (DelAer, n = 47) received exercise information for 6 months followed by 6 months of supervised aerobic exercise (stationary cycling). End points were lumbar spine, hip and whole-body BMD measured by dual-energy x-ray absorptiometry with secondary end points of lean and fat mass, appendicular skeletal muscle mass, and neuromuscular strength. ANOVA was used to compare the exercise groups with DelAer at 6 and 12 months. Results: There was a between-group difference in BMD for ImpRes and DelAer at the spine (6 months, P = 0.039; 12 months, P = 0.035) and femoral neck (6 months, P = 0.050), with decline attenuated in ImpRes (~-1.0% vs ~-2.0%). Compared with DelAer, ImpRes increased appendicular skeletal muscle at 6 months (0.3 kg, P = 0.045) and improved muscle strength at 6 and 12 months (P <= 0.012) by 9%-34%. A limitation was inclusion of well-functioning patients. Conclusion: Combined impact loading and resistance exercise attenuates bone loss at the spine and enhances overall musculoskeletal function in PCa patients undergoing ADT.

Details

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

Source: InCites

Metrics

72 Record Views
76 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types
Domestic collaboration
International collaboration
Citation topics
1 Clinical & Life Sciences
1.112 Palliative Care
1.112.297 Cancer Survivors
Web Of Science research areas
Sport Sciences
ESI research areas
Clinical Medicine
Logo image