Journal article
Exercise mode specificity for preserving spine and hip bone mineral density in prostate cancer patients
Medicine & Science in Sports & Exercise, Vol.51(4), pp.607-614
2019
Abstract
Purpose: Androgen deprivation therapy (ADT) in men with prostate cancer (PCa) is associated with an array of adverse effects, including reduced bone mineral density (BMD) predisposing patients to increased fracture risk. Our purpose was to examine the effects of targeted exercise modes on BMD in men with PCa undergoing ADT.
Methods: Between 2009 and 2012, 154 PCa patients 43-90 yr old on ADT were randomized to exercise targeting the musculoskeletal system (impact loading + resistance training [ImpRes], n = 57) supervised for 12 months, cardiovascular and muscular systems (aerobic + resistance training, n = 50) supervised for 6 months followed by a 6-month home-based program, or delayed aerobic exercise (DelAer, n = 47) received exercise information for 6 months followed by 6 months of supervised aerobic exercise (stationary cycling). End points were lumbar spine, hip and whole-body BMD measured by dual-energy x-ray absorptiometry with secondary end points of lean and fat mass, appendicular skeletal muscle mass, and neuromuscular strength. ANOVA was used to compare the exercise groups with DelAer at 6 and 12 months.
Results: There was a between-group difference in BMD for ImpRes and DelAer at the spine (6 months, P = 0.039; 12 months, P = 0.035) and femoral neck (6 months, P = 0.050), with decline attenuated in ImpRes (~-1.0% vs ~-2.0%). Compared with DelAer, ImpRes increased appendicular skeletal muscle at 6 months (0.3 kg, P = 0.045) and improved muscle strength at 6 and 12 months (P <= 0.012) by 9%-34%. A limitation was inclusion of well-functioning patients.
Conclusion: Combined impact loading and resistance exercise attenuates bone loss at the spine and enhances overall musculoskeletal function in PCa patients undergoing ADT.
Details
- Title
- Exercise mode specificity for preserving spine and hip bone mineral density in prostate cancer patients
- Authors/Creators
- R.U. Newton (Author/Creator) - Edith Cowan UniversityD.A. Galvão (Author/Creator) - Edith Cowan UniversityN. Spry (Author/Creator) - Edith Cowan UniversityD. Joseph (Author/Creator) - Sir Charles Gairdner HospitalS.K. Chambers (Author/Creator) - Edith Cowan UniversityR.A. Gardiner (Author/Creator) - Royal Brisbane and Women's HospitalB.A. Wall (Author/Creator) - Murdoch UniversityK.A. Bolam (Author/Creator) - Karolinska InstitutetD.R. Taaffe (Author/Creator) - The University of Queensland
- Publication Details
- Medicine & Science in Sports & Exercise, Vol.51(4), pp.607-614
- Publisher
- Lippincott Williams & Wilkins
- Identifiers
- 991005541352807891
- Copyright
- © 2019 by the American College of Sports Medicine
- Murdoch Affiliation
- School of Psychology and Exercise Science
- Language
- English
- Resource Type
- Journal article
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