Journal article
Exerkines and long-term synaptic potentiation: Mechanisms of exercise-induced neuroplasticity
Frontiers in Neuroendocrinology, Vol.66, Art. 100993
2022
Abstract
Physical exercise may improve cognitive function by modulating molecular and cellular mechanisms within the brain. We propose that the facilitation of long-term synaptic potentiation (LTP)-related pathways, by products induced by physical exercise (i.e., exerkines), is a crucial aspect of the exercise-effect on the brain. This review summarizes synaptic pathways that are activated by exerkines and may potentiate LTP. For a total of 16 exerkines, we indicated how blood and brain exerkine levels are altered depending on the type of physical exercise (i.e., cardiovascular or resistance exercise) and how they respond to a single bout (i.e., acute exercise) or multiple bouts of physical exercise (i.e., chronic exercise). This information may be used for designing individualized physical exercise programs. Finally, this review may serve to direct future research towards fundamental gaps in our current knowledge regarding the biophysical interactions between muscle activity and the brain at both cellular and system levels.
Details
- Title
- Exerkines and long-term synaptic potentiation: Mechanisms of exercise-induced neuroplasticity
- Authors/Creators
- W.A.J. Vints (Author/Creator) - Lithuanian Sports UniversityO. Levin (Author/Creator) - Lithuanian Sports UniversityH. Fujiyama (Author/Creator) - Murdoch UniversityJ. Verbunt (Author/Creator) - Maastricht UniversityN. Masiulis (Author/Creator) - Lithuanian Sports University
- Publication Details
- Frontiers in Neuroendocrinology, Vol.66, Art. 100993
- Publisher
- Elsevier Inc.
- Identifiers
- 991005546021207891
- Copyright
- © 2022 The Authors.
- Murdoch Affiliation
- Centre for Healthy Ageing; Centre for Molecular Medicine and Innovative Therapeutics; Health Futures Institute
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.5 Neuroscience
- 1.5.767 Hippocampal Neurogenesis
- Web Of Science research areas
- Endocrinology & Metabolism
- Neurosciences
- ESI research areas
- Neuroscience & Behavior