Journal article
Experimental models of porcine post-weaning colibacillosis and their relationship to post-weaning diarrhoea and digestive disorders as encountered in the field
Veterinary Microbiology, Vol.72(3-4), pp.295-310
2000
Abstract
The aim of this study was to develop a reliable model system of porcine post-weaning colibacillosis, and in doing so to assess the primary relationship of enterotoxigenic Escherichia coli to post-weaning diarrhoea and digestive disorders as encountered in the field. Six sequential experiments were carried out using 168 SPF piglets weaned into an optimal controlled environment at 28 days of age. The piglets were allocated to 23 treatment groups, 17 of which were inoculated either orally or intragastrically with enterotoxigenic strains of E. coli (LT+, STI+, STII+) possessing adhesive factors including K88 (F4). The piglets were challenged either once (Day 4 post-weaning) or on several days post-weaning, with the challenge load for each inoculation varying from 108 to 1012 CFU. Overall 14.5% of inoculated pigs developed severe illness and died: these had lesions in their digestive tracts typical of colibacillosis. Diarrhoea occurred on at least 1 day in 50% of inoculated pigs, but was transient (1.7 days on average), appeared very soon after challenge (sometimes within half a day), and was accompanied by signs of depression and low weight gain. Generally a prompt recovery then occurred. In the second 2 weeks post-inoculation daily weight gain reached the same level in most inoculated groups of pigs as in the uninoculated controls. Only a small number of pigs developed a chronic enteritis lasting several days, as is typically observed in field cases. Diarrhoea was more common in the piglets that were tested adhesive positive to the K88 fimbriae receptor, but the disorders were no more severe in these animals. The response of all pigs depended primarily on the inoculum used, and especially on the challenge load. Although enterotoxigenic E. coli are clearly important in the aetiology of post-weaning diarrhoea, other factors are also required for the production of the chronic post-weaning digestive disorders and ill-thrift that are commonly encountered in commercial piggeries.
Details
- Title
- Experimental models of porcine post-weaning colibacillosis and their relationship to post-weaning diarrhoea and digestive disorders as encountered in the field
- Authors/Creators
- F. Madec (Author/Creator) - Centre National d'Etudes Vétérinaires et Alimentaires, Zoopole les Croix, BP 53, 22440, Ploufragan, France.N. Bridoux (Author/Creator) - Centre National d'Etudes Vétérinaires et Alimentaires, Zoopole les Croix, BP 53, 22440, Ploufragan, France.S. Bounaix (Author/Creator) - Centre National d'Etudes Vétérinaires et Alimentaires, Zoopole les Croix, BP 53, 22440, Ploufragan, France.R. Cariolet (Author/Creator) - Centre National d'Etudes Vétérinaires et Alimentaires, Zoopole les Croix, BP 53, 22440, Ploufragan, France.Y. Duval-Iflah (Author/Creator) - Institut National de la Recherche AgronomiqueD.J. Hampson (Author/Creator) - Murdoch UniversityA. Jestin (Author/Creator) - Centre National d'Etudes Vétérinaires et Alimentaires, Zoopole les Croix, BP 53, 22440, Ploufragan, France.
- Publication Details
- Veterinary Microbiology, Vol.72(3-4), pp.295-310
- Publisher
- Elsevier BV
- Identifiers
- 991005544068007891
- Copyright
- © 2000 Elsevier Science B.V.
- Murdoch Affiliation
- School of Veterinary and Biomedical Sciences
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 3 Agriculture, Environment & Ecology
- 3.51 Dairy & Animal Sciences
- 3.51.208 Poultry Nutrition
- Web Of Science research areas
- Microbiology
- Veterinary Sciences
- ESI research areas
- Plant & Animal Science