Journal article
Experimental models on effects of psychostimulants
The Neuropsychiatric Complications of Stimulant Abuse, Vol.120, pp.107-129
2015
Abstract
Psychostimulants are a diverse group of substances that cause an increase in psychomotor activity at least in part through their actions on catecholaminergic systems including the dopaminergic mesolimbic pathways. Animal models used to study addiction are based on the psychomotor stimulant theory of addiction. The basics of this theory are that the reinforcing effects and the addition liabilities of the drugs can be predicted from their ability to induce psychomotor activation. This approach focuses on the ability of the drugs to directly control the animal's behavior and to induce psychomotor stimulation, and is consistent with the behavioral definition of addiction and behavioral sensitization. Animal experiments have the advantage over clinical studies of lower variation and fewer confounding effects.
Details
- Title
- Experimental models on effects of psychostimulants
- Authors/Creators
- S. Kõks (Author/Creator) - University of Tartu
- Publication Details
- The Neuropsychiatric Complications of Stimulant Abuse, Vol.120, pp.107-129
- Publisher
- Elsevier
- Identifiers
- 991005543501107891
- Copyright
- © 2015 Elsevier Inc.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.5 Neuroscience
- 1.5.77 Dopamine and Neuromodulation
- Web Of Science research areas
- Neurosciences
- Psychiatry
- Substance Abuse
- ESI research areas
- Neuroscience & Behavior