Journal article
Expression of CCR6 on B cells in systemic lupus erythematosus patients
Clinical Rheumatology, Vol.36(6), pp.1453-1456
06/2017
Abstract
B cells are known to play a dominant pathogenic role in autoimmune conditions such as systemic lupus erythematosus (SLE) and rheumatoid arthritis. In recent times, the chemokine receptor CCR6 and its cognate ligand CCL20 have been shown to play a role in the fundamental kinetics of germinal centres and B cell responses. As CCR6 is found on B cells and is upregulated after activation, we investigated the expression of CCR6 on naive, pre-germinal centre (GC), GC/plasma cell and memory B cells in peripheral B cells of SLE patients and healthy controls using flow cytometry. Pre-germinal centre B cells are found in lower proportions and the expression of CCR6 is increased on B cells of SLE patients, suggesting a role for the chemokine pair in the pathogenesis of the disease. Further studies are needed to explore these preliminary results.
Details
- Title
- Expression of CCR6 on B cells in systemic lupus erythematosus patients
- Authors/Creators
- A.Y.S. Lee (Author/Creator) - University of TasmaniaJ.L. Bannan (Author/Creator) - Menzies Research InstituteM.J. Adams (Author/Creator) - University of TasmaniaH. Körner (Author/Creator) - Anhui Medical University
- Publication Details
- Clinical Rheumatology, Vol.36(6), pp.1453-1456
- Publisher
- SpringerNature
- Identifiers
- 991005540846307891
- Copyright
- © 2017 Springer International Publishing AG
- Murdoch Affiliation
- School of Veterinary and Life Sciences
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
18 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.6 Immunology
- 1.6.1007 Chemokine Signaling
- Web Of Science research areas
- Rheumatology
- ESI research areas
- Clinical Medicine