Expression of Class II Cytokine Genes in Children’s Skin

P. Reemann; E. Reimann; S. Suutre; M. Paavo; U. Loite; O. Porosaar; K. Abram; H. Silm; E. Vasar; S. Kõks; K. Kingo

doi:10.2340/00015555-1717

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Expression of Class II Cytokine Genes in Children’s Skin

Journal article

Open access

Peer reviewed

Expression of Class II Cytokine Genes in Children’s Skin

P. Reemann, E. Reimann, S. Suutre, M. Paavo, U. Loite, O. Porosaar, K. Abram, H. Silm, E. Vasar, S. Kõks, …

Acta Dermato Venereologica, Vol.94(4), pp.386-392

2014

DOI: https://doi.org/10.2340/00015555-1717

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Abstract

Immune regulation of the skin plays an important role in susceptibility and development of illnesses. The aim of our study was to localise the interleukin (IL)-10 family of cytokines, in children’s skin and to determine possible age-related differences in the expression level. The mRNA expression level of IL10, IL19, IL20, IL22, IL24, IL26, IL28B, IL29 and their receptors IL10RA, IL10RB, IL20RA, IL20RB, IL22RA1, IL22RA2, IL28RA was compared in skin biopsies of children and adults and in childrens’ skin cells by quantitative real-time PCR (qRT-PCR). Immunohistochemistry was performed to confirm the qRT-PCR findings. We found age-related differences in the expression of IL10RB, IL20, IL20RA, IL22RA1, IL22RA2, IL26 and IL28RA genes. Cell type-dependent expression of IL10 family cytokines was apparent in the skin. In addition to previously known differences in systemic immunological response of adults and children, the present results reveal differences in immune profile of adult and juvenile skin.

Details

Title: Expression of Class II Cytokine Genes in Children’s Skin
Authors/Creators: P. Reemann (Author/Creator)
E. Reimann (Author/Creator)
S. Suutre (Author/Creator)
M. Paavo (Author/Creator)
U. Loite (Author/Creator)
O. Porosaar (Author/Creator)
K. Abram (Author/Creator)
H. Silm (Author/Creator)
E. Vasar (Author/Creator)
S. Kõks (Author/Creator)
K. Kingo (Author/Creator)
Publication Details: Acta Dermato Venereologica, Vol.94(4), pp.386-392
Publisher: Acta Dermato-Venereologica
Identifiers: 991005540759807891
Copyright: © 2014 Acta Dermato-Venereologica.
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.6 Immunology; 1.6.487 Regulatory T Cells
Web Of Science research areas: Dermatology
ESI research areas: Clinical Medicine