Journal article
Expression of IL-2 receptor p55 and p75 chains by human B lymphocytes: effects of activation and differentiation
Immunology, Vol.72(2), pp.167-173
02/1991
Abstract
Whilst B cells in human blood can be shown to express interleukin-2 receptor (IL-2R) p55 and p75 chains, using a high-sensitivity immunofluorescence procedure, fresh tonsil B cells did not show detectable levels of expression. Culture of tonsil B cells led to low levels of expression of the p55 chain of the IL-2R, an effect which was dependent on protein synthesis. The level of expression of IL-2R chains could be modulated by culturing in the presence of a number of factors which activate B cells. p55 levels were more readily modulated than p75 levels. IL-4 and combinations of IL-4 with anti-IgM, IL-2 or tumour necrosis factor-beta (TNF-beta) modulated p55 levels, but IL-5 did not. Changes in IL-2R expression were small when compared with other B-cell activation markers such as CD23. When unfractionated tonsil cells were activated with a polyclonal stimulus, the major change was the expression of p55 by T-cell blasts--p75 expression remained low in T and B cells, and p55 expression by B cells remained low.
Details
- Title
- Expression of IL-2 receptor p55 and p75 chains by human B lymphocytes: effects of activation and differentiation
- Authors/Creators
- H. Zola (Author/Creator)H. Weedon (Author/Creator)G.R. Thompson (Author/Creator)M.C. Fung (Author/Creator)E. Ingley (Author/Creator)A.J. Hapel (Author/Creator)
- Publication Details
- Immunology, Vol.72(2), pp.167-173
- Publisher
- Wiley-Blackwell
- Identifiers
- 991005545545607891
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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