Expressional changes in the intracellular melanogenesis pathways and their possible role the pathogenesis of vitiligo

K. Kingo; E. Aunin; M. Karelson; R. Rätsep; H. Silm; E. Vasar; S. Kõks

doi:10.1016/j.jdermsci.2008.03.013

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Expressional changes in the intracellular melanogenesis pathways and their possible role the pathogenesis of vitiligo

Journal article

Peer reviewed

Expressional changes in the intracellular melanogenesis pathways and their possible role the pathogenesis of vitiligo

K. Kingo, E. Aunin, M. Karelson, R. Rätsep, H. Silm, E. Vasar and S. Kõks

Journal of Dermatological Science, Vol.52(1), pp.39-46

2008

DOI: https://doi.org/10.1016/j.jdermsci.2008.03.013

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Abstract

Background Main pathway in human melanocytes through which signal from the melanocortin system reaches the melanogenesis enzymes is cAMP/PKA pathway and it is modulated by Wnt and MAPK pathways. In our previous study we established significant increase of melanocortin receptor expression in unaffected skin of vitiligo patients compared to healthy subjects. Objective The aim of this study was to assess the gene expression profile of the intracellular signalling pathways linking melanocortin system with enzymes involved in melanogenesis. Methods Using QRT-PCR method, mRNA expression levels of eight genes related to signal transduction from the melanocortin system to melanogenesis enzymes was measured in lesional and non-lesional skin of vitiligo patients and in the skin of healthy control subjects. Following genes were analyzed in the study: MITF, CREB1, p38, USF1, PIK3CB (PI3K), RPS6KB1, LEF1 and BCL2. Results The mRNA levels of MITF, LEF1, p38, PIK3CB and RPS6KB1 were decreased in lesional skin of vitiligo patients compared to skin of healthy control subjects. We also found increased expression of USF1 and BCL2 in non-lesional skin of vitiligo patients compared to skin of healthy control subjects. mRNA levels of MITF and BCL2 were decreased in lesional skin of vitiligo patients compared to non-lesional skin of vitiligo patients. Conclusions Present study indicates increased expression of the genes of the intracellular melanogenesis pathway in the non-lesional skin of vitiligo patients. This finding suggests activation of melanogenesis pathway in the non-lesional skin of vitiligo.

Details

Title: Expressional changes in the intracellular melanogenesis pathways and their possible role the pathogenesis of vitiligo
Authors/Creators: K. Kingo (Author/Creator) - University of Tartu
E. Aunin (Author/Creator) - University of Tartu
M. Karelson (Author/Creator) - University of Tartu
R. Rätsep (Author/Creator) - University of Tartu
H. Silm (Author/Creator) - University of Tartu
E. Vasar (Author/Creator) - University of Tartu
S. Kõks (Author/Creator) - University of Tartu
Publication Details: Journal of Dermatological Science, Vol.52(1), pp.39-46
Publisher: Elsevier Ireland Ltd
Identifiers: 991005542804107891
Copyright: © 2008 Japanese Society for Investigative Dermatology
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.158 Dermatology - General; 1.158.918 Melanogenesis Mechanisms
Web Of Science research areas: Dermatology
ESI research areas: Clinical Medicine