Journal article
Extended “Timed Up and Go” assessment as a clinical indicator of cognitive state in Parkinson's disease
Journal of the Neurological Sciences, Vol.375, pp.86-91
2017
Abstract
Objective
To evaluate a modified extended Timed Up and Go (extended-TUG) assessment against a panel of validated clinical assessments, as an indicator of Parkinson's disease (PD) severity and cognitive impairment.
Methods
Eighty-seven participants with idiopathic PD were sequentially recruited from a Movement Disorders Clinic. An extended-TUG assessment was employed which required participants to stand from a seated position, walk in a straight line for 7 m, turn 180° and then return to the start, in a seated position. The extended-TUG assessment duration was correlated to a panel of clinical assessments, including the Unified Parkinson's Disease Rating Scale (MDS-UPDRS), Quality of Life (PDQ-39), Scales for Outcomes in Parkinson's Disease (SCOPA-Cog), revised Addenbrooke's Cognitive Index (ACE-R) and Barratt's Impulsivity Scale 11 (BIS-11).
Results
Extended-TUG time was significantly correlated to MDS-UPDRS III score and to SCOPA-Cog, ACE-R (p < 0.001) and PDQ-39 scores (p < 0.01). Generalized linear models determined the extended-TUG to be a sole variable in predicting ACE-R or SCOPA-Cog scores. Patients in the fastest extended-TUG tertile were predicted to perform 8.3 and 13.4 points better in the SCOPA-Cog and ACE-R assessments, respectively, than the slowest group. Patients who exceeded the dementia cut-off scores with these instruments exhibited significantly longer extended-TUG times.
Conclusions
Extended-TUG performance appears to be a useful indicator of cognition as well as motor function and quality of life in PD, and warrants further evaluation as a first line assessment tool to monitor disease severity and response to treatment. Poor extended-TUG performance may identify patients without overt cognitive impairment form whom cognitive assessment is needed.
Details
- Title
- Extended “Timed Up and Go” assessment as a clinical indicator of cognitive state in Parkinson's disease
- Authors/Creators
- T. Evans (Author/Creator) - The University of Notre Dame AustraliaA. Jefferson (Author/Creator) - Perron Institute for Neurological and Translational ScienceM. Byrnes (Author/Creator) - The University of Western AustraliaS. Walters (Author/Creator) - The University of Western AustraliaS. Ghosh (Author/Creator) - The University of Western AustraliaF.L. Mastaglia (Author/Creator) - The University of Western AustraliaB. Power (Author/Creator) - The University of Notre Dame AustraliaR.S. Anderton (Author/Creator) - The University of Western Australia
- Publication Details
- Journal of the Neurological Sciences, Vol.375, pp.86-91
- Publisher
- Elsevier BV
- Identifiers
- 991005541865907891
- Copyright
- © 2017 Elsevier B.V.
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.52 Neurodegenerative Diseases
- 1.52.67 Parkinson's Disease
- Web Of Science research areas
- Clinical Neurology
- Neurosciences
- ESI research areas
- Neuroscience & Behavior