Extensive HLA class I allele promiscuity among viral CTL epitopes

N. Frahm; K. Yusim; T.J. Suscovich; S. Adams; J. Sidney; P. Hraber; H.S. Hewitt; C.H. Linde; D.G. Kavanagh; T. Woodberry; L.M. Henry; K. Faircloth; J. Listgarten; C. Kadie; N. Jojic; K. Sango; N.V. Brown; E. Pae; M.T. Zaman; F. Bihl; A. Khatri; M. John; S. Mallal; F.M. Marincola; B.D. Walker; A. Sette; D. Heckerman; B.T.M. Korber; C. Brander

doi:10.1002/eji.200737365

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Extensive HLA class I allele promiscuity among viral CTL epitopes

Journal article

Peer reviewed

Extensive HLA class I allele promiscuity among viral CTL epitopes

N. Frahm, K. Yusim, T.J. Suscovich, S. Adams, J. Sidney, P. Hraber, H.S. Hewitt, C.H. Linde, D.G. Kavanagh, T. Woodberry, …

European Journal of Immunology, Vol.37(9), pp.2419-2433

09/2007

DOI: https://doi.org/10.1002/eji.200737365

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Abstract

Promiscuous binding of T helper epitopes to MHC class II molecules has been well established, but few examples of promiscuous class I-restricted epitopes exist. To address the extent of promiscuity of HLA class I peptides, responses to 242 well-defined viral epitopes were tested in 100 subjects regardless of the individuals' HLA type. Surprisingly, half of all detected responses were seen in the absence of the originally reported restricting HLA class I allele, and only 3% of epitopes were recognized exclusively in the presence of their original allele. Functional assays confirmed the frequent recognition of HLA class I-restricted T cell epitopes on several alternative alleles across HLA class I supertypes and encoded on different class I loci. These data have significant implications for the understanding of MHC class I-restricted antigen presentation and vaccine development.

Details

Title: Extensive HLA class I allele promiscuity among viral CTL epitopes
Authors/Creators: N. Frahm (Author/Creator)
K. Yusim (Author/Creator)
T.J. Suscovich (Author/Creator)
S. Adams (Author/Creator)
J. Sidney (Author/Creator)
P. Hraber (Author/Creator)
H.S. Hewitt (Author/Creator)
C.H. Linde (Author/Creator)
D.G. Kavanagh (Author/Creator)
T. Woodberry (Author/Creator)
L.M. Henry (Author/Creator)
K. Faircloth (Author/Creator)
J. Listgarten (Author/Creator)
C. Kadie (Author/Creator)
N. Jojic (Author/Creator)
K. Sango (Author/Creator)
N.V. Brown (Author/Creator)
E. Pae (Author/Creator)
M.T. Zaman (Author/Creator)
F. Bihl (Author/Creator)
A. Khatri (Author/Creator)
M. John (Author/Creator)
S. Mallal (Author/Creator)
F.M. Marincola (Author/Creator)
B.D. Walker (Author/Creator)
A. Sette (Author/Creator)
D. Heckerman (Author/Creator)
B.T.M. Korber (Author/Creator)
C. Brander (Author/Creator)
Publication Details: European Journal of Immunology, Vol.37(9), pp.2419-2433
Publisher: John Wiley & Sons Ltd.
Identifiers: 991005542490107891
Copyright: © 2007 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
Murdoch Affiliation: Centre for Clinical Immunology and Biomedical Statistics
Language: English
Resource Type: Journal article

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Collaboration types: Industry collaboration; Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.66 HIV; 1.66.46 HIV Pathogenesis
Web Of Science research areas: Immunology
ESI research areas: Immunology